Titre du document / Document title

Drug-resistant HIV-1 in the semen of men receiving antiretroviral therapy with acute sexually transmitted infections

Auteur(s) / Author(s)

TAYLOR Stephen ^{(1 2)} ; TARIQ SADIQ S. ⁽³⁾ ; WELLER Ian ⁽³⁾ ; KAYE Steve ⁽⁴⁾ ; WORKMAN Judith ⁽¹⁾ ; CANE Patricia A. ⁽¹⁾ ; BENNETT Julie ⁽⁴⁾ ; COPAS Andrew J. ⁽³⁾ ; DRAKE Susan M. ⁽²⁾ ; PILLOY Deenan ^{(1 4)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ HPA Antiviral Susceptibility Reference Unit, Division of Immunity and Infection, University of Birmingham, ROYAUME-UNI
⁽²⁾ Department of Sexual Medicine Birmingham, Heartlands Hospital, ROYAUME-UNI
⁽³⁾ Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, University College, London, ROYAUME-UNI
⁽⁴⁾ Department of Virology, Royal Free and University College Medical School, University College London, ROYAUME-UNI

Résumé / Abstract

Sexually transmitted infections may enhance the sexual transmission of HIV-1. It is possible that loss of virological control in patients with such infections receiving antiretroviral therapy (ART) may even facilitate the transmission of drug-resistant HIV. We have recently demonstrated that in those on maximally suppressive ART this effect is reduced. We have examined the virus obtained from the blood plasma and seminal plasma of six HIV-1-infected men receiving poorly suppressive ART with acute urethritis for the presence of drug resistance-associated mutations. In four men with gonorrhoea the blood and seminal plasma HIV-1 had mutations conferring reduced susceptibility to one or more available drugs. In one of these men the viral load of drug-resistant virus in seminal plasma was 20-fold higher during gonorrhoea than following antibiotic treatment, with no change in blood plasma viral load. We conclude that in the presence of suboptimal ART, sexually transmitted infections may enhance the spread of drug-resistant HIV-1.

Revue / Journal Title

Antiviral therapy   ISSN 1359-6535 

Source / Source

2003, vol. 8, n^o5, pp. 479-483 [5 page(s) (article)] (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

International Medical Press, London, ROYAUME-UNI  (1996) (Revue)

Mots-clés anglais / English Keywords

Infection ; Virus ; Retroviridae ; Lentivirus ; Human immunodeficiency virus ; Transmission from man to man ; Drug combination ; Antiviral ; Chemotherapy ; Treatment ; Resistance ; HIV-1 virus ; Viral load ; Semen ; Biological fluid ; Male ; Sexually transmitted disease ; Human ;

Mots-clés français / French Keywords

Infection ; Virus ; Retroviridae ; Lentivirus ; Virus immunodéficience humaine ; Transmission homme homme ; Association médicamenteuse ; Antiviral ; Chimiothérapie ; Traitement ; Résistance ; Virus HIV1 ; Charge virale ; Sperme ; Liquide biologique ; Mâle ; Maladie sexuellement transmissible ; Homme ;

Mots-clés espagnols / Spanish Keywords

Infección ; Virus ; Retroviridae ; Lentivirus ; Human immunodeficiency virus ; Transmisión hombre hombre ; Asociación medicamentosa ; Antiviral ; Quimioterapia ; Tratamiento ; Resistencia ; HIV-1 virus ; Carga vírica ; Esperma ; Líquido biológico ; Macho ; Enfermedad de transmisión sexual ; Hombre ;

Localisation / Location

INIST-CNRS, Cote INIST : 27047, 35400011474658.0150