Titre du document / Document title

Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice

Auteur(s) / Author(s)

VIBERG Henrik ⁽¹⁾ ; FREDRIKSSON Anders ⁽¹⁾ ; ERIKSSON Per ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Environmental Toxicology, Uppsala University, Norbyvägen 18A, 75236 Uppsala, SUEDE

Résumé / Abstract

Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice. Flame retardants are used to suppress or inhibit combustion processes in an effort to reduce the risk of fire. One class of flame retardants, polybrominated diphenyl ethers (PBDEs), are present and increasing in the environment and in human milk. The present study shows that neonatal exposure to 2,2',4,4',5,5'-hexaBDE (PBDE 153), a PBDE persistent both in environment and in human milk, can induce developmental neurotoxic effects, such as changes in spontaneous behaviour (hyperactivity), impairments in learning and memory, and reduced amounts of nicotinic receptors, effects that get worse with age. Neonatal NMRI male mice were orally exposed on day 10 to 0.45, 0.9, or 9.0 mg of PBDE 153/kg of body weight. Spontaneous behaviour (locomotion, rearing, and total activity) was observed in 2-, 4-, and 6-month-old mice, Morris water maze at an age of 6 months. The behaviour tests showed that the effects were dose-response and time-response related. Animals showing defects in learning and memory also showed significantly reduced amounts of nicotinic receptors in hippocampus, using α-bungarotoxin binding assay. The observed developmental neurotoxic effects seen for PBDE 153 are similar to those seen for PBDE 99 and for certain PCBs. Furthermore, PBDEs appear to as potent as the PCBs.

Revue / Journal Title

Toxicology and applied pharmacology   ISSN 0041-008X   CODEN TXAPA9 

Source / Source

2003, vol. 192, n^o2, pp. 95-106 [12 page(s) (article)] (1 p.1/2)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, San Diego, CA, ETATS-UNIS  (1959) (Revue)

Mots-clés anglais / English Keywords

Nervous system diseases ; Vertebrata ; Mammalia ; Rodentia ; Cholinergic receptor ; Hippocampus ; Mouse ; Newborn animal ; Memory ; Learning ; Behavior ; Toxicity ; Flame retardant ;

Mots-clés français / French Keywords

Système nerveux pathologie ; Vertebrata ; Mammalia ; Rodentia ; Phényle éther(polybromo) ; Diphényl éther(polybromo) ; Récepteur cholinergique ; Hippocampe ; Souris ; Animal nouveau né ; Mémoire ; Apprentissage ; Comportement ; Toxicité ; Retardateur flamme ;

Mots-clés espagnols / Spanish Keywords

Sistema nervioso patología ; Vertebrata ; Mammalia ; Rodentia ; Receptor colinérgico ; Hipocampo ; Ratón ; Animal recién nacido ; Memoria ; Aprendizaje ; Conducta ; Toxicidad ; Retardador llama ;

Mots-clés d'auteur / Author Keywords

Spontaneous behaviour ; Learning and memory ; Cholinergic system ; Neonatal ; Flame retardants ; Polybrominated diphenyl ethers ;

Localisation / Location

INIST-CNRS, Cote INIST : 9067, 35400011327989.0010