Titre du document / Document title
The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity
Auteur(s) / Author(s)
TURNBULL Jonathan J. (1) ;
NAGLE Michael J. (2) ;
SEIBEL Jürgen F. (1) ;
WELFORD Richard W. D. (1) ;
GRANT Guy H. (2) ;
SCHOFIELD Christopher J. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, The Department of Chemistry, South Parks Road, Oxford OX1 3QY, ROYAUME-UNI
(2) The Physical and Theoretical Chemistry Laboratory, The Department of Chemistry, South Parks Road, Oxford OX1 3QZ, ROYAUME-UNI
Résumé / Abstract
Anthocyanidin synthase (ANS), an iron(II) and 2-oxoglutarate (20G) dependent oxygenase, catalyses the penultimate step in anthocyanin biosynthesis by oxidation of the 2R,3S,4S-cis-leucoanthocyanidins. It has been believed that in vivo the products of ANS are the anthocyanidins. However, in vitro studies on ANS using optically active cis- and trans-leucocyanidin substrates identified cyanidin as only a minor product; instead both quercetin and dihydroquercetin are products with the distribution being dependent on the C-4 stereochemistry of the leucocyanidin substrates.
Revue / Journal Title
Bioorganic & medicinal chemistry letters
ISSN
0960-894X
Source / Source
2003, vol. 13, n
o21, pp. 3853-3857 [5 page(s) (article)]
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Amsterdam, PAYS-BAS
(1991)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 22446, 35400011247369.0470
Nº notice refdoc (ud4) : 15176584
