Titre du document / Document title

Pharmacological effect and toxicity of alkaloids from Gelsemium elegans Benth.

Auteur(s) / Author(s)

RUJJANAWATE C. ⁽¹⁾ ; KANJANAPOTHI D. ⁽¹⁾ ; PANTHONG A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Laboratory of Natural Products, Faculty of Medicine, Chulabhorn Research Institute, Research Center at Chiangmai University, Chiangmai University, Chiangmai 50200, THAILANDE

Résumé / Abstract

Gelsemium elegans Benth. (Loganiaceae), a toxic plant indigenous to southeastern Asia, is well known among hilltribes as an effective means for committing suicide. A crude alkaloidal fraction from its leaves was isolated by conventional acid-base extraction. Tests in animals showed that the alkaloids exerted analgesic and anti-inflammatory effects. At a lethal dose the alkaloids produced violent clonic convulsions that led to respiratory failure. Since the convulsions could be prevented by pentobarbital or diazepam and potentiated by reserpine, it is postulated that the alkaloids act centrally against GABA action.

Revue / Journal Title

Journal of ethnopharmacology   ISSN 0378-8741   CODEN JOETD7 

Source / Source

2003, vol. 89, n^o1, pp. 91-95 [5 page(s) (article)] (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1978) (Revue)

Mots-clés anglais / English Keywords

Neurological disorder ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Loganiaceae ; Pharmacognosy ; Plant origin ; Medicinal plant ; Mouse ; Rat ; Animal ; Pharmacological activity ; Biological activity ; Analgesic ; Antiinflammatory agent ; Toxicity ; Convulsion ; Alkaloid ; Plant leaf ;

Mots-clés français / French Keywords

Trouble neurologique ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Loganiaceae ; Gelsemium elegans ; Pharmacognosie ; Origine végétale ; Plante médicinale ; Souris ; Rat ; Animal ; Propriété pharmacologique ; Activité biologique ; Analgésique ; Antiinflammatoire ; Toxicité ; Convulsion ; Alcaloïde ; Feuille végétal ;

Mots-clés espagnols / Spanish Keywords

Trastorno neurológico ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Loganiaceae ; Farmacognosia ; Origen vegetal ; Planta medicinal ; Ratón ; Rata ; Animal ; Propiedad farmacológica ; Actividad biológica ; Analgésico ; Antiinflamatorio ; Toxicidad ; Convulsión ; Alcaloide ; Hoja vegetal ;

Mots-clés d'auteur / Author Keywords

Gelsemium elegans ; Crude alkaloidal traction ; Analgesic and anti-inflammatory effect ; Clonic convulsion ; GABA ;

Localisation / Location

INIST-CNRS, Cote INIST : 18028, 35400011247427.0130