Titre du document / Document title

Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro

Auteur(s) / Author(s)

WYDE Philip R. ⁽¹⁾ ; CHETTY Srikrishna N. ⁽¹⁾ ; JEWELL Alan M. ⁽¹⁾ ; BOIVIN Guy ⁽²⁾ ; PIEDRA Pedro A. ^{(1 3)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Departments of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, ETATS-UNIS
⁽²⁾ Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Que., ANGOLA
⁽³⁾ Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, ETATS-UNIS

Résumé / Abstract

Human metapneumovirus (hMPV) is a newly recognized pathogen that like its better-known relative, human respiratory syncytial virus (hRSV), appears to be ubiquitous and an important cause of respiratory disease in diverse subpopulations. No antivirals or vaccines are currently approved for the treatment or prevention of hMPV infections. However, ribavirin is licensed to treat serious hRSV-induced infections in children and immune globulin designed for intravenous administration (IVIG) and palivizumab (Synagis), a humanized monoclonal antibody preparation, have been utilized as alternatives to vaccines for preventing or reducing the severity of infections caused by this virus. Because both ribavirin and IVIG have broad viral specificities, studies were performed to compare the ability of these two agents to inhibit the replication of hRSV and hMPV in tissue culture-based assays. Two experimental chemotherapeutic agents (i.e. VP14637 and JNJ2408068) and different antibody preparations were included in this testing for comparison. Ribavirin and the IVIG utilized were found to have equivalent antiviral activity against hMPV and hRSV. In contrast, except for antisera specifically raised against hMPV, all of the other materials tested had marked activity only against hRSV.

Revue / Journal Title

Antiviral research   ISSN 0166-3542   CODEN ARSRDR 

Source / Source

2003, vol. 60, n^o1, pp. 51-59 [9 page(s) (article)] (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1981) (Revue)

Mots-clés anglais / English Keywords

Virus ; Mononegavirales ; Paramyxoviridae ; Pneumovirinae ; Pneumovirus ; Nucleosidic analog ; In vitro ; Biological activity ; Human respiratory syncytial virus ; Antiviral ; Comparative study ; Intravenous administration ; Immunoglobulins ; Ribavirin ;

Mots-clés français / French Keywords

Virus ; Mononegavirales ; Paramyxoviridae ; Pneumovirinae ; Pneumovirus ; Human metapneumovirus ; Analogue nucléoside ; In vitro ; Activité biologique ; Virus respiratoire syncytial humain ; Antiviral ; Etude comparative ; Voie intraveineuse ; Immunoglobuline ; Ribavirine ;

Mots-clés espagnols / Spanish Keywords

Virus ; Mononegavirales ; Paramyxoviridae ; Pneumovirinae ; Pneumovirus ; Análogo nucleósido ; In vitro ; Actividad biológica ; Human respiratory syncytial virus ; Antiviral ; Estudio comparativo ; Vía intravenosa ; Inmunoglobulina ; Ribavirina ;

Mots-clés d'auteur / Author Keywords

RSV: hMPV ; Human metapneumovirus ; Antiviral ; Respiratory syncytial virus ; Ribavirin ; IVIG ; JNJ2408068 ;

Localisation / Location

INIST-CNRS, Cote INIST : 18839, 35400011468742.0060