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Titre du document / Document title

The nuclear protein HMGBI, a new kind of chemokine?

Auteur(s) / Author(s)

DEGRYSE Bernard ; DE VIRGILIO Maddalena ;

Résumé / Abstract

The chromosomal protein HMGBI is now regarded as a proinflammatory cytokine. Importantly, HMGB1 has chemotactic activity suggesting its involvement in the early and late events of the inflammatory reaction. Therefore, HMGB1 has all the hallmarks of a chemokine (chemotactic cytokine). We propose to classify HMGBI into a new group of proteins unrelated structurally to chemokines but having chemokine-like functions, and to name this class CLF (chemokine-like functions). The CLF class should include other unrelated molecules such as urokinase and its receptor, cytokines macrophage migration inhibitory factor (MIF) and interleukin (IL)-6, anaphylatoxin C5a, ribosomal protein S19, and thioredoxin that have similar chemokine-like activities. This innovative concept may lead to the identification of new therapeutic targets.

Revue / Journal Title

FEBS letters    ISSN  0014-5793   CODEN FEBLAL 

Source / Source

2003, vol. 553, no1-2, pp. 11-17 [7 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Oxford, ROYAUME-UNI  (1968) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 13934, 35400011442333.0020

Nº notice refdoc (ud4) : 15143246



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