Titre du document / Document title
The nuclear protein HMGBI, a new kind of chemokine?
Auteur(s) / Author(s)DEGRYSE Bernard
DE VIRGILIO Maddalena
Résumé / Abstract
The chromosomal protein HMGBI is now regarded as a proinflammatory cytokine. Importantly, HMGB1 has chemotactic activity suggesting its involvement in the early and late events of the inflammatory reaction. Therefore, HMGB1 has all the hallmarks of a chemokine (chemotactic cytokine). We propose to classify HMGBI into a new group of proteins unrelated structurally to chemokines but having chemokine-like functions, and to name this class CLF (chemokine-like functions). The CLF class should include other unrelated molecules such as urokinase and its receptor, cytokines macrophage migration inhibitory factor (MIF) and interleukin (IL)-6, anaphylatoxin C5a, ribosomal protein S19, and thioredoxin that have similar chemokine-like activities. This innovative concept may lead to the identification of new therapeutic targets.
Revue / Journal TitleFEBS letters
Source / Source
2003, vol. 553, no
1-2, pp. 11-17 [7 page(s) (article)]
Langue / Language
Editeur / Publisher
Elsevier, Oxford, ROYAUME-UNI
Localisation / Location
INIST-CNRS, Cote INIST : 13934, 35400011442333.0020
Nº notice refdoc (ud4) : 15143246