Titre du document / Document title

Locally delivered minocycline microspheres for the treatment ol periodontitis in smokers

Auteur(s) / Author(s)

PAQUETTE David ; ORINGER Richard ; LESSEM Jan ; OFFENBACHER Steven ; GENCO Robert ; PERSSON G. Rutger ; SANTUCCI Edward A. ; WILLIAMS Ray C. ;

Résumé / Abstract

Aim: The aim of the present analysis of a larger phase 3 clinical trial was to evaluate the efficacy of 1 mg minocycline hydrochloride microencapsulated in 3 mg of resorbable polymer, subgingivally administered as an adjunct to scaling and root planing (SRP) in smokers with chronic periodontitis. Material and Methods: Two hundred and seventy-one patients who smoked were randomized to one of three treatment groups: (1) SRP alone, (2) SRP plus vehicle (polymer without minocycline) or (3) SRP plus minocycline microspheres. Full mouth SRP was performed for all groups at baseline, and vehicle or minocycline microspheres were administered to the appropriate patients at all periodontal pockets 5 mm at baseline, 3 and 6 months. Efficacy was evaluated over 9 months. Results: Significantly greater pocket depth reductions with SRP plus adjunctive minocycline microsphere treatment were observed at 1, 6 and 9 months (p<0.05) versus control treatments. At 9 months, smokers treated with SRP plus minocycline microspheres exhibited a pocket depth reduction of 1.19 mm from baseline, as compared to 0.90 mm for smokers treated with SRP alone. The efficacy of adjunctive minocycline microspheres was consistent among all tested smoking subcohorts, including those based on gender, age and smoking exposures. Conclusion: These data indicate that treatment with SRP plus locally delivered minocycline microspheres is more effective than SRP alone in reducing pocket depths in smokers with periodontitis.

Revue / Journal Title

Journal of clinical periodontology   ISSN 0303-6979 

Source / Source

2003, vol. 30, n^o9, pp. 787-794 [8 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1974) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 16273, 35400011439271.0040