Titre du document / Document title

Controlled, randomized trial in maintenance treatment of intravenous buprenorphine dependence with naltrexone, methadone or buprenorphine: a novel study

Auteur(s) / Author(s)

AHMADI J. ⁽¹⁾ ; AHMADI K. ⁽¹⁾ ; OHAERI J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Shiraz University of Medical Sciences, Kuwait University, KOWEIT

Résumé / Abstract

Aims To test the effect of a 50-mg day^-1 dose of naltrexone in the maintenance treatment of intravenous-buprenorphine dependence in comparison with a 50-mg day^-1 dose of methadone and also a 5-mg day^-1 dose of buprenorphine over a 24-week treatment period. Participants Two hundred and four intravenous-buprenorphine-dependent patients who met the DSM-IV criteria for opioid dependence were randomized to three equal groups and were treated in a clinic in Iran where they were also offered a weekly 0.5-h counselling session, in 2002. Findings The mean age was 31.2 years (range 17-53). The majority [63.2%] was between 20 and 34 years of age. The educational level of most of them [55.4%] was between 6 and 12 years of study. Completion rates by groups were 83.8% for the 50-mg dose methadone group, 58.8% for the 5-mg dose buprenorphine group and 20.6% for the 50-mg dose naltrexone group (P= 0.000). Retention in the 50-mg methadone group was significantly better than in the 5-mg dose buprenorphine group (P= 0.001) and the 50-mg dose naltrexone group (P = 0.000). Retention in the 5-mg buprenorphine group was significantly better than in the 50-mg naltrexone dose group (P = 0.000). Conclusions Evaluation of the Iranian experience on this subject may be useful for other countries.

Revue / Journal Title

European journal of clinical investigation   ISSN 0014-2972 

Source / Source

2003, vol. 33, n^o9, pp. 824-829 [6 page(s) (article)] (29 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1970) (Revue)

Mots-clés anglais / English Keywords

Morphinan derivatives ; Opiates ; Dependence ; Antagonist ; Methadone ; Sublingual administration ; Chemotherapy ; Treatment ; Naltrexone ; Human ; Narcotic analgesic ; Buprenorphine ;

Mots-clés français / French Keywords

Pharmacodépendance ; Morphinane dérivé ; Opiacés ; Dépendance ; Antagoniste ; Méthadone ; Voie sublinguale ; Chimiothérapie ; Traitement ; Naltrexone ; Homme ; Analgésique narcotique ; Buprénorphine ;

Mots-clés espagnols / Spanish Keywords

Morphinano derivado ; Opiados ; Dependencia ; Antagonista ; Metadona ; Vía sublingual ; Quimioterapia ; Tratamiento ; Naltrexona ; Hombre ; Analgésico narcotico ; Buprenorfina ;

Mots-clés d'auteur / Author Keywords

Buprenorphine dependence ; naltrexone ; oral methadone ; retention in treatment ; sublingual buprenorphine ;

Localisation / Location

INIST-CNRS, Cote INIST : 5808, 35400011434322.0130