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Titre du document / Document title

Lifestyle, parity, menstrual and reproductive factors and risk of gallbladder cancer

Auteur(s) / Author(s)

PANDEY M. (1) ; SHUKLA V. K. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Surgical Oncology, Regional Cancer Centre, Medical College PO, Thiruvananthapuram, Kerala 695 011, INDE
(2) Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, INDE

Résumé / Abstract

Together with thyroid cancer, cancer of the gallbladder is the only non-sex hormone-related cancer displaying a female preponderance, with incidence being 3-4 times more common among women. We carried out this study to evaluate the role of menstrual, reproductive and lifestyle factors in gallbladder carcinogenesis. A case-control study involving 64 newly diagnosed cases of gallbladder cancer and 101 cases of cholelithiasis was carried out. A detailed menstrual and reproductive history was illustrated beside detailed lifestyle history, in particular consumption of betel nut, tobacco and alcohol and smoking, odds ratio was calculated. Mean age of the patients with cancer was 51 ± 1.2 years while it was 40.9 ± 1.2 years for gallstones; 69% of cancer patients and 90% of gallstones patients were females. More than half of the cancer patients (53%) and 43% of the gallstone patients were illiterate. A past history of typhoid was present in 22% of cancer patients and 13% of gallstone patients, while 35% of cancer and 25% of gallstone patients were chewers, 18.1 and 9.9% were smokers, and 10% of cancer and 2% of gallstone patients consumed alcohol. Mean age of menarche was 13.4 ± 1.2 years among female patients with cancer while it was 14.0 ± 1.4 years for gallstone patients. Higher age at menarche (> 13 years, OR 2.48, 95% confidence interval (Cl) 1.16-5.3), higher number of childbirths (>3 births, OR 3.92; 95% Cl 1.4-10.3), higher number of pregnancies (>3 pregnancies, OR 6.66, 95% Cl 1.8-23.4), and higher age at last childbirth ( > 25 years, OR 2.97, 95% Cl 1.04-8.5) were found to have significantly higher risk of developing gallbladder cancer. In conclusion, tobacco chewing and smoking are associated with increased odds of gallbladder cancer. Similarly early menarche, late menopause, multiple pregnancies and childbirth increased the risk of gallbladder cancer.

Revue / Journal Title

European journal of cancer prevention    ISSN  0959-8278 

Source / Source

2003, vol. 12, no4, pp. 269-272 [4 page(s) (article)] (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams and Wilkins, Hagerstown, MD, ETATS-UNIS  (1991) (Revue)

Mots-clés anglais / English Keywords

Biliary tract disease

;

Digestive diseases

;

Age criterion

;

Retrospective

;

Carcinogenesis

;

Case control study

;

Parity

;

Menstrual cycle

;

Quality of life

;

Lifestyle Preference Questionnaire

;

Risk factor

;

Sex ratio

;

Incidence

;

Epidemiology

;

Human

;

Gallbladder

;

Malignant tumor

;

Mots-clés français / French Keywords

Voie biliaire pathologie

;

Appareil digestif pathologie

;

Critère âge

;

Rétrospective

;

Carcinogenèse

;

Etude cas témoin

;

Parité

;

Cycle menstruel

;

Qualité vie

;

Lifestyle Preference Questionnaire

;

Facteur risque

;

Sex ratio

;

Incidence

;

Epidémiologie

;

Homme

;

Vésicule biliaire

;

Tumeur maligne

;

Mots-clés espagnols / Spanish Keywords

Vía biliar patología

;

Aparato digestivo patología

;

Criterio edad

;

Retrospectiva

;

Carcinogénesis

;

Estudio caso control

;

Paridad

;

Ciclo menstrual

;

Calidad vida

;

Lifestyle Preference Questionnaire

;

Factor riesgo

;

Proporción de sexos

;

Incidencia

;

Epidemiología

;

Hombre

;

Vesícula biliar

;

Tumor maligno

;

Localisation / Location

INIST-CNRS, Cote INIST : 22623, 35400011272508.0040

Nº notice refdoc (ud4) : 15068448



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