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Titre du document / Document title

Genistein as an anti-inflammatory agent

Auteur(s) / Author(s)

VERDRENGH M. ; JONSSON I. M. ; HOLMDAHL R. ; TARKOWSKI A. ;

Résumé / Abstract

Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice. Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined. Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of oxazolone-specific antibodies. Histologically, mice exposed to genistein and immunized with collagen II displayed somewhat lower degree of inflammation and joint destruction. In addition, serum levels of autoantibodies to collagen II were significantly lower following genistein-treatment in immunized mice. Conclusion: We conclude that genistein exerts evident anti-inflammatory properties affecting granulocytes, monocytes, and lymphocytes.

Revue / Journal Title

Inflammation research    ISSN  1023-3830 

Source / Source

2003, vol. 52, no8, pp. 341-346 [6 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Birkhäuser, Basel, SUISSE  (1995) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 14514, 35400011272771.0040

Nº notice refdoc (ud4) : 15062243



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