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Titre du document / Document title

Lowering effects in plasma cholesterol and body weight by mycelial extracts of two mushrooms: Agaricus blazai and Lentinus edodes

Auteur(s) / Author(s)

MEE-HYANG Kweon (1) ; KWON Suk-Tae (2) ; KWON Suk-Hyung (3) ; MA Min-Suk (3) ; YOUNG IN PARK (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Graduate School of Biotechnology, Korea University, Seoul 136-701, COREE, REPUBLIQUE DE
(2) Department of Genetic Engineering, Sungkyunkwan University, COREE, REPUBLIQUE DE
(3) RexGene Biotech Co., Ltd., COREE, REPUBLIQUE DE

Résumé / Abstract

The effects of protein-bound polysaccharides (A-PBP and L-PBP) that were extracted from the mycelia of two edible mushrooms, namely Agaricus blazai and Lentinus edodes, on serum cholesterol and body weight were investigated in mice and female volunteers. Six groups of Male Balb/c mice were fed six kinds of diet supplement- solutions composed of L-PBP, A-PBP, chitosan, and other fiber constituents, for 30 days under the normal diet. Ninety female volunteers were also supplemented for 8 weeks with six kinds of capsules including control and five test groups as the same manners (two times a day, 4 capsules). From 12 days after feeding of L-PBP (Group I) and A-PBP (Group II), the weight of mice began to reduce as compared with control, whereas that of Group III fed chitosan was decreased 15 days after feeding. Group IV and Group V, which were fed mixture of L-PBP, A-PBP, chitosan, and other dietary fiber, were more significant in lowering weight. After 4 weeks of the supplementation in women, their serum LDL-cholesterol level and body weights in Group I and II were reduced, but Group III taken with chitosan capsule showed weaker effect than Group I and II. After 8 weeks, LDL-cholesterol content in the sera of Group I (132.5 mg/ dL) and II (131.5 mg/dL) was decreased to ideal level (125.4 and 122.8 mg/dL) for healthy blood vessel. In the case of Group IV supplemented with mixture of L-PBP, A-PBP. and chitosan, the weight-reduction effect (11.8%) and hypocholesterolemic effect (11.0%) was most significant, indicating their synergistic action. These data suggested that the weight-controlling and hypolipidemic effect of L-PBP and A-PBP was involved, at least in part, in absorption of cholesterol as their role of dietary fiber, as well as cholesterol metabolism.

Revue / Journal Title

San'oeb misaengmul haghoeji    ISSN  0257-2389 

Source / Source

2002, vol. 30, no4, pp. 402-409 [8 page(s) (article)] (23 ref.)

Langue / Language

Coréen
Revue : Japonais

Editeur / Publisher

Korean Society for Applied Microbiology, Seoul, COREE, REPUBLIQUE DE  (1973-2001) (Revue)

Mots-clés anglais / English Keywords

Thallophyta

;

Fungi

;

Basidiomycetes

;

Agaricus

;

Lipoprotein LDL

;

Polysaccharide

;

Protein

;

Lentinus edodes

;

Cholesterol

;

Mots-clés français / French Keywords

Thallophyta

;

Fungi

;

Basidiomycetes

;

Agaricus

;

Lipoprotéine LDL

;

Polyoside

;

Protéine

;

Lentinus edodes

;

Cholestérol

;

Mots-clés espagnols / Spanish Keywords

Thallophyta

;

Fungi

;

Basidiomycetes

;

Agaricus

;

Lipoproteína LDL

;

Poliósido

;

Proteína

;

Lentinus edodes

;

Colesterol

;

Mots-clés d'auteur / Author Keywords

Protein-bound polysaccharide

;

Agaricus blazai

;

Lentinus edodes

;

LDL-cholesterol

;

body weight

;

Localisation / Location

INIST-CNRS, Cote INIST : 26481, 35400011237451.0170

Nº notice refdoc (ud4) : 15054599



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