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Titre du document / Document title

Polyphenols of Melaleuca quinquenervia leaves - pharmacological studies of grandinin

Auteur(s) / Author(s)

MOHARRAM F. A. (1) ; MARZOUK M. S. (2) ; EL-TOUMY S. A. A. (2) ; AHMED A. A. E. (3) ; ABOUTABL E. A. (4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo, EGYPTE
(2) Chemistry of Tannins and Proteins Department, National Research Centre, Tahrir St., Dokki, Cairo, EGYPTE
(3) Pharmacology and Toxicology Department, Faculty of Pharmacy, Helwan University., Cairo, EGYPTE
(4) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Kuwait University, KOWEIT

Résumé / Abstract

Four polyphenolic acid derivatives and three ellagitannins were isolated from the leaves of Melaleuca quinquenervia (Clav.) S. T. Blake for the first time. Their structures were elucidated as gallic acid (1), ellagic acid (2), 3-O-methylellagic acid (3), 3,4,3'-tri-O-methylellagic acid (4), 2,3-O-hexahydroxydiphenoyl-(α/β)-D-4C1-glucopyranose (5), castalin (6) and grandinin (7) on the basis of chemical, mass spectrometric (-ve ESI-MS) and spectroscopic (UV, 1H-, 13C NMR, 1H,1H-, 1H,13C-COSY, 1H,1H-TOCSY and HMBC) analyses. Grandinin (the major compound) showed radical scavenging properties by its reaction with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical [EC50 = 4.3 ± 0.3 μg mL-1]. It was found to be relatively nontoxic in mice [LD50 = 316 mg Kg-1 b.wt.]. It exhibited a significant dose-dependent (35-70 mg Kg-1) hypoglycemic effect by significantly reducing blood glucose level in basal condition and after heavy glucose load in normal mice. Moreover, it reduced the elevated blood glucose level in STZ-induced diabetic mice. In addition, grandinin reduced the elevated blood urea nitrogen and serum lipid peroxides in STZ-induced diabetic mice.

Revue / Journal Title

PTR. Phytotherapy research    ISSN  0951-418X 

Source / Source

2003, vol. 17, no7, pp. 767-773 [7 page(s) (article)] (29 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Chichester, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Myrtaceae

;

Plant origin

;

Medicinal plant

;

Pharmacognosy

;

Biological activity

;

Structural analysis

;

Chemical isolation

;

Mouse

;

Animal

;

Uremia

;

Lipids

;

Peroxidation

;

Antioxidant

;

Free radical

;

Radical scavenger

;

Hypoglycemic agent

;

Polyphenol

;

Plant leaf

;

Mots-clés français / French Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Myrtaceae

;

Melaleuca quinquenervia

;

Origine végétale

;

Plante médicinale

;

Pharmacognosie

;

Activité biologique

;

Analyse structurale

;

Isolement chimique

;

Souris

;

Animal

;

Urémie

;

Lipide

;

Peroxydation

;

Antioxydant

;

Radical libre

;

Intercepteur radical

;

Hypoglycémiant

;

Polyphénol

;

Feuille végétal

;

Mots-clés espagnols / Spanish Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Myrtaceae

;

Origen vegetal

;

Planta medicinal

;

Farmacognosia

;

Actividad biológica

;

Análisis estructural

;

Aislamiento químico

;

Ratón

;

Animal

;

Uremia

;

Lípido

;

Peroxidación

;

Antioxidante

;

Radical libre

;

Interceptor radical

;

Hipoglicemiante

;

Polifenol

;

Hoja vegetal

;

Mots-clés d'auteur / Author Keywords

Melaleuca quinquenervia (Myrtaceae)

;

C-glycosidic ellagitannins

;

radical scavenging properties

;

hypoglycemic effect

;

lipid peroxides

;

blood urea nitrogen

;

Localisation / Location

INIST-CNRS, Cote INIST : 21695, 35400011143204.0130

Nº notice refdoc (ud4) : 15047141



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