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Titre du document / Document title

Relaxant effect of Foeniculum vulgare on isolated Guinea pig tracheal chains

Auteur(s) / Author(s)

BOSKABADY M. H. (1) ; KHATAMI A. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Deptartment of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, IRAN, REPUBLIQUE ISLAMIQUE D'

Résumé / Abstract

Foeniculum vulgare is a grassy plant which is believed to have several therapeutic effects including anti-asthmatic uses. We have therefore studied the relaxant (bronchodilatory) effect of this plant on isolated guinea pig tracheal chains and its possible mechanism(s). The bronchodilatory effects of aqueous and ethanol extracts. essential oil, and 1 μM theophylline in comparison with controls were examined by their relaxant effects on precontracted isolated tracheal chains of guinea pig in two different conditions including: non-incubated tissues (group 1) and incubated tissues with 1 μM propranolol and 1 μM chlorpheniramine (group 2). In addition, the anticholinergic effects of essential oil and 10nM atropine were tested by performing the cumulative log-concentration-response curves of methacholine induced contraction of tracheal chains compared with that of saline (for all experimental conditions n = 8). In group I and 2 experiments, essential oil and theophylline and, in group 1, ethanol extract showed significant relaxant effects compared to those of saline and ethanol, respectively. Although bronchodilatory effects of essential oil was lower than theophylline in group 1 (p < 0.01), there was no significant difference between the effect of ethanol extract in both groups and the effect of essential oil in group 2 experiments with that of theophylline. The relaxant effect obtained in group 2 for essential oil was significantly greater (p < 0.05) and for ethanol extract non-significantly lower than those of group 1 experiments. The results also showed non-parallel rightward shift of methacholine-response curves and nonsignificant difference of EC50 (the effective concentration of inethacholine, causing 50% of maximum response) obtained in the presence of essential oil compared to those of saline. These results indicated bronchodilatory effects of ethanol extract and essential oil from Foeniculum vulgare which is not due to inhibitory properties of the plant on muscarinic and histamine H1 and/or an stimulatory effect on β2-adrenergic receptors.

Revue / Journal Title

Pharmaceutical biology    ISSN  1388-0209 

Source / Source

2003, vol. 41, no3, pp. 211-215 [5 page(s) (article)] (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

Swets & Zeitlinger, Lisse, PAYS-BAS  (1998) (Revue)

Mots-clés anglais / English Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Umbelliferae

;

Bronchodilation

;

Vasodilation

;

In vitro

;

Comparative study

;

Essential oil

;

Extract

;

Mechanism of action

;

Treatment

;

Trachea

;

Guinea pig

;

Animal

;

Plant origin

;

Medicinal plant

;

Foeniculum vulgare

;

Mots-clés français / French Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Umbelliferae

;

Bronchodilatation

;

Vasodilatation

;

In vitro

;

Etude comparative

;

Huile essentielle

;

Extrait

;

Mécanisme action

;

Traitement

;

Trachée

;

Cobaye

;

Animal

;

Origine végétale

;

Plante médicinale

;

Foeniculum vulgare

;

Mots-clés espagnols / Spanish Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Umbelliferae

;

Broncodilatación

;

Vasodilatación

;

In vitro

;

Estudio comparativo

;

Aceite esencial

;

Extracto

;

Mecanismo acción

;

Tratamiento

;

Tráquea

;

Cobayo

;

Animal

;

Origen vegetal

;

Planta medicinal

;

Foeniculum vulgare

;

Localisation / Location

INIST-CNRS, Cote INIST : 1635, 35400011973899.0120

Nº notice refdoc (ud4) : 15025077



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