Titre du document / Document title

Modifications of the immune responsiveness in patients with autoimmune thyroiditis: Evidence for a systemic immune alteration

Auteur(s) / Author(s)

CIAMPOLILLO A. ⁽¹⁾ ; GUASTAMACCHIA E. ⁽¹⁾ ; AMATI L. ⁽²⁾ ; MAGRONE T. ⁽²⁾ ; MUNNO I. ⁽³⁾ ; JIRILLO E. ⁽³⁾ ; TRIGGIANI V. ⁽¹⁾ ; FALLACARA R. ⁽⁴⁾ ; TAFARO E. ⁽⁴⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Section of Internal Medicine, Endocrinology and Metabolic Disease, Department of Emergency and Organ Transplantation, University of Bari, ITALIE
⁽²⁾ Scientific Institute for Digestive Disease, Castellana Grotte, Bari, ITALIE
⁽³⁾ Immunology, University of Bari, ITALIE
⁽⁴⁾ Endocrinology, University of Bari, ITALIE

Résumé / Abstract

Hashimoto's thyroiditis, the most common form of autoimmune thyroid disease, is characterised by lymphocytic infiltration of the thyroid gland, gradual destruction of the organ and production of thyroid specific auto antibodies (antithyroid peroxidase and antithyroglobulin antibodies). There are evidences that cast doubt on the pathogenetic role of these antibodies in thyroid autoimmunity. It is very likely that cellular destruction is mediated by other cellular mechanisms, such as auto reactive T-lymphocytes, natural killer and cytokines. However, other studies performed in animal models have led to the conclusion that organ specific autoimmune thyroiditis should be regarded as a polygenic disease with a penetrance that is strongly influenced by environmental factors. According to our recent results, patients affected by autoimmune thyroiditis exhibited a decreased percentage of NK and CD25 + bearing cells significantly in comparison to normal controls. Altogether these data indicated that in the patients with autoimmune thyroid disease a certain degree of peripheral immune deficiency was present.

Revue / Journal Title

Current pharmaceutical design   ISSN 1381-6128 

Source / Source

2003, vol. 9, n^o24, pp. 1946-1950 [5 page(s) (article)] (57 ref.)

Langue / Language

Anglais

Editeur / Publisher

Bentham, Sharjah, EMIRATS ARABES UNIS  (1995) (Revue)

Mots-clés anglais / English Keywords

Autoimmune disease ; Immunopathology ; Thyroid diseases ; Endocrinopathy ; Lymphocyte ; Immune deficiency ; Natural killer cell ; Cellular immunity ; Biological marker ; Autoantibody ; Immune response ; Bibliographic review ; Review ; Functionality ; Immune system ; Pathophysiology ; Human ; Hashimoto thyroiditis ;

Mots-clés français / French Keywords

Maladie autoimmune ; Immunopathologie ; Thyroïde pathologie ; Endocrinopathie ; Lymphocyte ; Immunodéficit ; Cellule NK ; Immunité cellulaire ; Marqueur biologique ; Autoanticorps ; Réponse immune ; Revue bibliographique ; Article synthèse ; Fonctionnalité ; Système immunitaire ; Physiopathologie ; Homme ; Thyroïdite Hashimoto ;

Mots-clés espagnols / Spanish Keywords

Enfermedad autoinmune ; Inmunopatología ; Tiroides patología ; Endocrinopatía ; Linfocito ; Inmunodeficiencia ; Célula NK ; Inmunidad celular ; Marcador biológico ; Autoanticuerpo ; Respuesta inmune ; Revista bibliográfica ; Artículo síntesis ; Funcionalidad ; Sistema inmunitario ; Fisiopatología ; Hombre ; Tiroiditis Hashimoto ;

Localisation / Location

INIST-CNRS, Cote INIST : 26320, 35400011230340.0050