RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Randomized double-blind study of the Reliefband as an adjunct to standard antiemetics in patients receiving moderately-high to highly emetogenic chemotherapy

Auteur(s) / Author(s)

TREISH Imad (1) ; SHORD Stacy (1) ; VALGUS John (1) ; HARVEY Donald (1) ; NAGY Jessica (1) ; STEGAL Jennifer (1) ; LINDLEY Celeste (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) University of North Carolina Hospitals, Manning Drive, Chapel Hill, NC 27514, ETATS-UNIS

Résumé / Abstract

Goals: Our goal was to evaluate the efficacy and tolerability of the Reliefband as an adjunct to standard antiemetics in patients receiving moderately-high to highly emetogenic chemotherapy. Patients and methods: Forty-nine adult cancer patients receiving moderately-high or highly emetogenic chemotherapy were randomized to receive either the active Reliefband (n=26) or an inactive device (n=23). Patients continued to receive all scheduled and as needed antiemetic agents as prescribed. The device was worn the day of chemotherapy administration for 5 days (days 1-5). Patients maintained a daily dairy of nausea severity, vomiting and retching episodes, and antiemetic medications taken. Each patient completed a Functional Living Index Emesis (FLIE) and a tolerability survey at the conclusion of the study. A Wilcoxon rank sum test was used to compare the number of vomiting episodes, severity of nausea and FLIE scores between the two groups. Main results: Patients wearing the active Relifband experienced less vomiting (Reliefband 1.9 versus inactive device 4.6 mean episodes; p=0.05), retching (1.4 versus 3.6 mean episodes; p=0.05), and nausea severity (0.91 versus 1.65 mean cm/day; p=0.01) over the 5-day period compared to patients wearing the inactive device. Vomiting was statistically significantly reduced during the delayed period (0.42 versus 1; p=0.032), whereas nausea was significantly reduced during the acute (0.71 versus 2.3; p=0.028) and delayed (1.8 versus 3.3; p=0.020) periods. FLIE scores did not differ between the two treatment groups (91 versus 80; p=0.088). Conclusions: This study suggests that patients receiving moderately-high to highly emetogenic chemotherapy who experience nausea and vomiting despite scheduled antiemetics may benefit from the use of the Reliefband as an adjunct to antiemetics. Limitations of this study include differences in risk factors for emesis, chemotherapy, and antiemetic regimens. A larger, better, controlled randomized study is needed to better define optimal use of this device.

Revue / Journal Title

Supportive care in cancer    ISSN  0941-4355 

Source / Source

2003, vol. 11, no8, pp. 516-521 [6 page(s) (article)] (32 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1993) (Revue)

Mots-clés anglais / English Keywords

Digestive diseases

;

Human

;

Alternative medicine

;

Combined treatment

;

Randomization

;

Double blind study

;

Folk medicine

;

Chinese medicine

;

Wrist

;

Acupuncture point

;

Electrical stimulus

;

Antiemetic

;

Complication

;

Toxicity

;

Treatment

;

Nausea

;

Vomiting

;

Antineoplastic agent

;

Chemotherapy

;

Malignant tumor

;

Mots-clés français / French Keywords

Appareil digestif pathologie

;

Homme

;

Médecine parallèle

;

Traitement associé

;

Randomisation

;

Etude double insu

;

Médecine traditionnelle

;

Médecine chinoise

;

Poignet

;

Point acupuncture

;

Stimulus électrique

;

Antiémétique

;

Complication

;

Toxicité

;

Traitement

;

Nausée

;

Vomissement

;

Anticancéreux

;

Chimiothérapie

;

Tumeur maligne

;

Mots-clés espagnols / Spanish Keywords

Aparato digestivo patología

;

Hombre

;

Medicina alternativa

;

Tratamiento asociado

;

Aleatorización

;

Estudio doble ciego

;

Medicina tradicional

;

Medicina china

;

Muñeca

;

Punto acupuntura

;

Estímulo eléctrico

;

Antiemético

;

Complicación

;

Toxicidad

;

Tratamiento

;

Nausea

;

Vómito

;

Anticanceroso

;

Quimioterapia

;

Tumor maligno

;

Mots-clés d'auteur / Author Keywords

Acustimulation

;

Transcutaneous electrical stimulation

;

Acupressure

;

Nausea

;

Vomiting

;

Chemotherapy

;

Reliefband

;

Localisation / Location

INIST-CNRS, Cote INIST : 26260, 35400011261865.0040

Nº notice refdoc (ud4) : 15017507



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas