Titre du document / Document title

The challenge of chronic insomnia: is non-nightly hypnotic treatment a feasible alternative?

Auteur(s) / Author(s)

HAJAK G. ⁽¹⁾ ; CLUYDTS R. ⁽²⁾ ; ALLAIN H. ⁽³⁾ ; ESTIVILL E. ⁽⁴⁾ ; PARRINO L. ⁽⁵⁾ ; TERZANO M. G. ⁽⁵⁾ ; WALSH J. K. ⁽⁶⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Psychiatry and Psychotherapy, University of Regensburg, ALLEMAGNE
⁽²⁾ Department of Psychology, Free University of Brussels, BELGIQUE
⁽³⁾ CHU de Rennes, Laboratoire de Pharmacologie Expérimentale et Clinique, Faculté de Medecine, Rennes, FRANCE
⁽⁴⁾ Institut Universitari Dexeus, Barcelona, ESPAGNE
⁽⁵⁾ Centro di Medicina del Sonno, Instituto di Neurologia, Università di Parma, ITALIE
⁽⁶⁾ Unity Sleep Medicine and Research Center, St. Luke's Hospital, Chesterfield, MO, ETATS-UNIS

Résumé / Abstract

The adverse effects of insomnia on health and quality of life are matters receiving increasing attention. Yet, surveys have consistently shown that most people suffering from insomnia do not seek medical help, perhaps, in part, because of a concern of becoming dependent on hypnotic medication. The treatment of chronic insomnia poses a particular dilemma in that continuous hypnotic treatment is restricted in many countries to a maximum of 4 weeks, and behavioural treatment is not readily available. Non-nightly hypnotic treatment of chronic insomnia offers a promising alternative option for the many patients whose symptoms do not necessitate nightly drug intake, allaying fears of psychological dependence on medication and respecting regulatory constraints on hypnotic use while providing patients with adequate symptom relief. The practical feasibility and efficacy of this approach has been demonstrated with zolpidem using various treatment regimens and study designs. So far, six clinical trials have been completed on over 4000 patients. Published results show effective treatment of insomnia without any evidence of either adverse event associated with a discontinuous regimen or increased hypnotic use over the treatment period.

Revue / Journal Title

European psychiatry   ISSN 0924-9338 

Source / Source

2003, vol. 18, n^o5, pp. 201-208 [8 page(s) (article)] (57 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Paris, FRANCE  (1991) (Revue)

Mots-clés anglais / English Keywords

Psychotropic ; Sleep disorder ; Human ; Review ; Toxicity ; Treatment efficiency ; Sedative ; Hypnotic ; Gabaergic agonist ; Gabaergic receptor A ; Agonist ; Zolpidem ; Day ; Feasibility ; Chemotherapy ; Treatment ; Chronic ; Insomnia ;

Mots-clés français / French Keywords

Psychotrope ; Trouble sommeil ; Imidazo pyridine dérivé ; Homme ; Article synthèse ; Toxicité ; Efficacité traitement ; Sédatif ; Hypnotique ; Stimulant gabaergique ; Récepteur gabaergique A ; Agoniste ; Zolpidem ; Jour ; Faisabilité ; Chimiothérapie ; Traitement ; Chronique ; Insomnie ;

Mots-clés espagnols / Spanish Keywords

Psicotropo ; Trastorno sueño ; Hombre ; Artículo síntesis ; Toxicidad ; Eficacia tratamiento ; Sedante ; Hipnótico ; Estimulante gabaérgico ; Receptor gabaminérgico A ; Agonista ; Zolpidem ; Día ; Practicabilidad ; Quimioterapia ; Tratamiento ; Crónico ; Insomnio ;

Mots-clés d'auteur / Author Keywords

Chronic insomnia ; Hypnotic medication ; Zolpidem ; Pharmacological treatment ;

Localisation / Location

INIST-CNRS, Cote INIST : 21224, 35400011228922.0010