Titre du document / Document title

Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract

Auteur(s) / Author(s)

SANO Atsushi ⁽¹⁾ ; YAMAKOSHI Jun ⁽¹⁾ ; TOKUTAKE Shoichi ⁽¹⁾ ; TOBE Koichiro ⁽¹⁾ ; KUBOTA Yoshiro ⁽²⁾ ; KIKUCHI Mamoru ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Research and Development Division, Kikkoman Corporation, 399 Noda, Noda, Chiba 278-0037, JAPON
⁽²⁾ Kikkoman General Hospital, 100 Miyazaki, Noda, Chiba 278-0005, JAPON

Résumé / Abstract

To confirm the absorption of proanthocyanidin (PA) into the human body, four healthy adults were administered 2.0 g of PA-rich grape seed extract (GSE). Blood were drawn before intake and 2 h after intake. Through the enzymatic treatment of sulfatase and β-glucuronidase, blood samples were analyzed by HPLC coupled with mass-spectrometry (LC/MS). Procyanidin B1 [epicatechin-(4β→8)-catechin] was detected in human serum 2 h after intake. Its concentration was 10.6 ± 2.5 nmol/l.

Revue / Journal Title

Bioscience, biotechnology, and biochemistry    ISSN  0916-8451 

Source / Source

2003, vol. 67, n^o5, pp. 1140-1143 [4 page(s) (article)] (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Japan Society for Bioscience Biotechnology and Agrochemistry, Tokyo, JAPON  (1992) (Revue)

Mots-clés d'auteur / Author Keywords

proanthocyanidin

;

procyanidin B1

;

absorption

;

grape seed extract

;

human

;

Localisation / Location

INIST-CNRS, Cote INIST : 8935, 35400011846921.0280