Titre du document / Document title

Treatment of severe erosive gingival lesions by topical application of clobetasol propionate in custom trays

Auteur(s) / Author(s)

GONZALEZ-MOLES Miguel Angel ⁽¹⁾ ; RUIZ-AVILA Isabel ⁽²⁾ ; RODRIGUEZ-ARCHILLA Alberto ⁽¹⁾ ; MORALES-GARCIA Patricia ⁽¹⁾ ; MESA-AGUADO Francisco ⁽¹⁾ ; BASCONES-MARTINEZ Antonio ⁽³⁾ ; BRAVO Manuel ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ University of Granada, ESPAGNE
⁽²⁾ Jaen General Hospital, ESPAGNE
⁽³⁾ University Complutense of Madrid, ESPAGNE

Résumé / Abstract

Objective. We sought to describe the response of patients with severe erosive gingival lesions to treatment with clobetasol propionate in Orabase paste administered in trays. The adverse effects were also recorded. Study design. A descriptive pretest/posttest clinical study with no control group (33 patients total) was developed. All patients received repeated applications of 0.05% clobetasol propionate plus 100,000 lU/cc of nystatin in Orabase paste. Over the 48-week period, the pain levels, ulcerations, presence of atrophy, and the patients' daily activities were recorded, and Likert scales were used to classify each outcome as either a complete recovery, excellent, good, poor, or failed. The presence of any adverse effect was also noted. Results. At the end of the study period, the pain and ulceration had disappeared (complete response) in 100% of the sample (33/33; 95% confidence interval = 89.4%-100%), and there was a complete recovery of daily activities and remission of atrophy in 93.9% (31/33; 95% confidence interval = 79.8%-99.3%) and 21.2% (7/33; 95% confidence interval = 9.0%-38.9%) of the patients, respectively. No adverse effects related to the treatment were observed. Conclusions. The application of an Orabase paste of 0.05% clobetasol 1 7-propionate plus 100,000 lU/cc of nystatin by means of a tray appears to be an efficacious treatment for severe erosive gingival lesions.

Revue / Journal Title

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics   ISSN 1079-2104 

Source / Source

2003, vol. 95, n^o6, pp. 688-692 [5 page(s) (article)] (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, St. Louis, MO, ETATS-UNIS  (1995) (Revue)

Mots-clés anglais / English Keywords

Periodontal disease ; Stomatology ; Clobetasol propionate ; Local administration ; Chemotherapy ; Corticosteroid ; Treatment ; Human ; Gingivitis ;

Mots-clés français / French Keywords

Parodontopathie ; Stomatologie ; Clobétasol propionate ; Voie locale ; Chimiothérapie ; Corticostéroïde ; Traitement ; Homme ; Gingivite ;

Mots-clés espagnols / Spanish Keywords

Parodontopatía ; Estomatología ; Clobetasol propionato ; Vía local ; Quimioterapia ; Corticoesteroide ; Tratamiento ; Hombre ; Gingivitis ;

Localisation / Location

INIST-CNRS, Cote INIST : 5101, 35400011836690.0090