Titre du document / Document title

Tramadol/paracetamol

Auteur(s) / Author(s)

MCCLELLAN Karen ⁽¹⁾ ; SCOTT Lesley J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Adis International Limited, Auckland, NOUVELLE-ZELANDE

Résumé / Abstract

The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain. Two tramadol/paracetamol 37.5/325mg tablets provided greater relief of dental pain over an 8-hour period than either agent alone, with a faster onset of action than tramadol alone and a longer duration of action than either agent as monotherapy. In patients with postoperative dental pain, two tramadol/paracetamol tablets (37.5/325mg) provided similar analgesia to hydrocodone/paracetamol 10/ 650mg over an 8-hour period. The addition of one or two tramadol/paracetamol 37.5/325mg tablets (up to four times daily) for 5 days to existing NSAID or cyclo-oxygenase-2 inhibitor analgesic therapy provided effective pain relief in patients with osteoarthritis flare pain. Tramadol/paracetamol 37.5/325mg provided similar efficacy to that of codeine/paracetamol 30/ 300mg in patients with chronic back pain in a 4-week, randomised, double-blind trial (a maximum of 10 tablets or capsules per day of the active drug).

Revue / Journal Title

Drugs   ISSN 0012-6667   CODEN DRUGAY 

Source / Source

2003, vol. 63, n^o11, pp. 1079-1086 [8 page(s) (article)] (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Adis International, Auckland, NOUVELLE-ZELANDE  (1962) (Revue)

Mots-clés anglais / English Keywords

Posology ; Toxicity ; Pain ; Treatment efficiency ; Interest ; Pharmacokinetic pharmacodynamic relationship ; Pharmacokinetics ; Human ; Review ; Tablet ; Oral administration ; Drug combination ; Analgesic ; Paracetamol ; Tramadol ;

Mots-clés français / French Keywords

Posologie ; Toxicité ; Douleur ; Efficacité traitement ; Intérêt ; Relation pharmacocinétique pharmacodynamie ; Pharmacocinétique ; Homme ; Article synthèse ; Comprimé ; Voie orale ; Association médicamenteuse ; Analgésique ; Paracétamol ; Tramadol ;

Mots-clés espagnols / Spanish Keywords

Posología ; Toxicidad ; Dolor ; Eficacia tratamiento ; Interés ; Relación farmacocinética farmacodinamia ; Farmacocinética ; Hombre ; Artículo síntesis ; Tableta ; Vía oral ; Asociación medicamentosa ; Analgésico ; Paracetamol ; Tramadol ;

Localisation / Location

INIST-CNRS, Cote INIST : 15326, 35400011833598.0050