Titre du document / Document title
Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics a dose-dependence study
Auteur(s) / Author(s)
JUDY William V. (1) ;
HARI Siva P. (2) ;
STOGSDILL W. W. (1) ;
JUDY Janet S. (1) ;
NAGUIB Yousry M. A. (2) ;
PASSWATER Richard (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) SIBR, Inc., 4112 20th Street West, Bradenton, FL 34205, ETATS-UNIS
(2) Soft Gel Technologies, Inc., 6982 Bandini Boulevard, Los Angeles, CA 90040, ETATS-UNIS
Résumé / Abstract
The antidiabetic activity of an extract from the leaves of Lagerstroemia speciosa standardized to 1% corosolic acid (Glucosol) has been demonstrated in a randomized clinical trial involving Type II diabetics (non-insulin-dependent diabetes mellitus, NIDDM). Subjects received a daily oral dose of Glucosol and blood glucose levels were measured. Glucosol at daily dosages of 32 and 48 mg for 2 weeks showed a significant reduction in the blood glucose levels. Glucosol in a soft gel capsule formulation showed a 30% decrease in blood glucose levels compared to a 20% drop seen with dry-powder filled hard gelatin capsule formulation (P < 0.001), suggesting that the soft gel formulation has a better bioavailability than a dry-powder formulation.
Revue / Journal Title
Journal of ethnopharmacology
ISSN
0378-8741
CODEN JOETD7
Source / Source
2003, vol. 87, n
o1, pp. 115-117 [3 page(s) (article)] (7 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Shanno, IRLANDE
(1978)
(Revue)
Mots-clés anglais / English Keywords
Endocrinopathy ;
Spermatophyta ;
Angiospermae ;
Dicotyledones ;
Lythraceae ;
Oral administration ;
Phytotherapy ;
Treatment ;
Hypoglycemic agent ;
Human ;
Non insulin dependent diabetes ;
Biological activity ;
Plant leaf ;
Extract ;
Plant origin ;
Medicinal plant ;
Mots-clés français / French Keywords
Endocrinopathie ;
Spermatophyta ;
Angiospermae ;
Dicotyledones ;
Lythraceae ;
Voie orale ;
Phytothérapie ;
Traitement ;
Hypoglycémiant ;
Homme ;
Diabète non insulinodépendant ;
Activité biologique ;
Feuille végétal ;
Extrait ;
Origine végétale ;
Plante médicinale ;
Mots-clés espagnols / Spanish Keywords
Endocrinopatía ;
Spermatophyta ;
Angiospermae ;
Dicotyledones ;
Lythraceae ;
Vía oral ;
Fitoterapia ;
Tratamiento ;
Hipoglicemiante ;
Hombre ;
Diabetes no insulinodependiente ;
Actividad biológica ;
Hoja vegetal ;
Extracto ;
Origen vegetal ;
Planta medicinal ;
Mots-clés d'auteur / Author Keywords
Type 11 diabetes ;
Blood glucose ;
Lagerstroemia speciosa ;
Glucosol# ;
Localisation / Location
INIST-CNRS, Cote INIST : 18028, 35400011985240.0190
Nº notice refdoc (ud4) : 14850984
