Titre du document / Document title

Food-borne radiolytic compounds (2-alkylcyclobutanones) may promote experimental colon carcinogenesis

Auteur(s) / Author(s)

RAUL Francis ⁽¹⁾ ; GOSSE Francine ⁽¹⁾ ; DELINCEE Henry ⁽²⁾ ; HARTWIG Andrea ⁽³⁾ ; MARCHIONI Eric ⁽⁴⁾ ; MIESCH Michel ⁽⁵⁾ ; WERNER Dalal ⁽⁶⁾ ; BURNOUF Dominique ⁽⁷⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Laboratoire d'Oncologie Nutritionnelle, 67000 Strasbourg, FRANCE
⁽²⁾ Bundesforschungsanstalt für Ernährung, 76131 Karlsruhe, ALLEMAGNE
⁽³⁾ Institut für Lebensmittelchemie und Toxikologie, Universität Karlsruhe, 76128 Karlsruhe, ALLEMAGNE
⁽⁴⁾ Laboratoire de Chimie Analytique et Sciences de l'Aliment (UMR 7512), Faculty de Pharmacie, Université Louis Pasteur, 67400 Illkirch, FRANCE
⁽⁵⁾ Laboratoire de Chimie Organique Synthétique (UMR 7123), Faculty de Chimie, Université Louis Pasteur, 67000 Strasbourg, FRANCE
⁽⁶⁾ Aérial, 67300 Schiltigheim, FRANCE
⁽⁷⁾ Groupe d'Epidémiologie Moléculaire du Cancer, 67000 Strasbourg, FRANCE

Résumé / Abstract

Food irradiation is acknowledged as a safe process to improve food quality by reducing microbial contamination. Information on the toxicological potential of 2-alkylcyclobutanones (2-ACBs), radiolytic derivatives of triglycerides found exclusively in irradiated food, is scarce. Wistar rats received daily a solution of highly pure 2-tetradecylcyclobutanone (2-tDCB) or 2-(tetradec-5'-enyl)-cyclobutanone (2-tDeCB) at a concentration of 0.005% in 1% ethanol as drinking fluid, while control animals received 1% ethanol. All animals received a single intraperitoneal injection of the chemical carcinogen azoxymethane (AOM) at Weeks 3 and 4. At 3 mo after AOM injection, no significant changes were observed in the total number of preneoplastic lesions in the colon of AOM controls and 2-ACB-treated animals. After 6 mo, the total number of tumors in the colon was threefold higher in the 2-ACB-treated animals than in the AOM controls. The colon of four of six AOM control rats exhibited only one small tumor (∼6 mm³). Multiple tumors were observed in four and three of six animals treated with 2-tDCB or 2-tDeCB, respectively. Medium (6 < S < 25 mm³) and larger (>25 mm³) tumors were detected only in 2-ACB-treated animals. This is the first demonstration that a compound found exclusively in irradiated dietary fats may promote colon carcinogenesis in animals treated with a chemical carcinogen.

Revue / Journal Title

Nutrition and cancer   ISSN 0163-5581   CODEN NUCADQ 

Source / Source

2002, vol. 44, n^o2, pp. 188-191 [4 page(s) (article)] (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Taylor& Francis, Philadelphia, PA, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Colonic disease ; Intestinal disease ; Digestive diseases ; Vertebrata ; Mammalia ; Rodentia ; Carcinogenesis ; Experimental tumor ; Colon ; Malignant tumor ; Experimental study ; Rat ; Animal model ; Animal ; Food ; Irradiated ;

Mots-clés français / French Keywords

Côlon pathologie ; Intestin pathologie ; Appareil digestif pathologie ; Vertebrata ; Mammalia ; Rodentia ; Triglycéride dérivé ; Carcinogenèse ; Tumeur expérimentale ; Côlon ; Tumeur maligne ; Etude expérimentale ; Rat ; Modèle animal ; Animal ; Aliment ; Irradié ;

Mots-clés espagnols / Spanish Keywords

Colón patología ; Intestino patología ; Aparato digestivo patología ; Vertebrata ; Mammalia ; Rodentia ; Carcinogénesis ; Tumor experimental ; Colón ; Tumor maligno ; Estudio experimental ; Rata ; Modelo animal ; Animal ; Alimento ; Irradiado ;

Localisation / Location

INIST-CNRS, Cote INIST : 20911, 35400011823227.0110