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Titre du document / Document title

Dissociation of ABH antigen expression from von Willebrand factor synthesis in endothelial cell lines

Auteur(s) / Author(s)

O'DONNELL James (1) ; LAFFAN Michael A. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, ROYAUME-UNI

Résumé / Abstract

ABO blood group determines plasma von Willebrand factor (VWF) levels and ABH antigens are present on VWF. To investigate whether ABO influences the rate of VWF synthesis. we performed stable transfection of A transferase in a phenotypically group-O endothelial cell line (EAhy926). A transferase expression did not affect the rate of VWF synthesis, Although high levels of A antigen were expressed on the cell surface, no A determinants were added to VWF synthesized within these cells. Further studies demonstrated H structures were not present on EAhy926-derived VWF, despite the fact that H antigen is constitutively expressed by these cells.

Revue / Journal Title

British journal of haematology    ISSN  0007-1048   CODEN BJHEAL 

Source / Source

2003, vol. 121, no6, pp. 928-931 [4 page(s) (article)] (12 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1955) (Revue)

Mots-clés anglais / English Keywords

Human

;

Established cell line

;

Endothelial cell

;

Synthesis

;

Willebrand factor

;

Antigen

;

ABO(H)-System

;

Blood group

;

Mots-clés français / French Keywords

Homme

;

Lignée cellulaire établie

;

Cellule endothéliale

;

Synthèse

;

Facteur Willebrand

;

Antigène

;

Système ABO(H)

;

Groupe sanguin

;

Mots-clés espagnols / Spanish Keywords

Hombre

;

Línea celular establecida

;

Célula endotelial

;

Síntesis

;

Factor Willebrand

;

Antígeno

;

Sistema ABO(H)

;

Grupo sanguíneo

;

Localisation / Location

INIST-CNRS, Cote INIST : 7597, 35400011981546.0160

Nº notice refdoc (ud4) : 14837373



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