Titre du document / Document title

The effect of vitamin D₃ on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients

Auteur(s) / Author(s)

BORISSOVA A-M ⁽¹⁾ ; TANKOVA T. ⁽¹⁾ ; KIRILOV G. ⁽¹⁾ ; DAKOVSKA L. ⁽¹⁾ ; KOVACHEVA R. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Endocrinology, University Hospital, Sofia, BULGARIE

Résumé / Abstract

The aim of this study was to evaluate the effect of vitamin D₃ supplementation on insulin secretion and insulin resistance. Ten females with type 2 diabetes being treated with oral hypoglycaemic agents and with normal serum and urine calcium levels were enrolled in the study. The study was conducted in March, when levels of vitamin D are lowest in our region. The level of plasma 25(OH)D was measured (normal range in winter 25-120 nmol/l). The first (FPIS) and second (SPIS) phases of insulin secretion were studied during IVGTT. Peripheral insulin resistance was measured. A group of 17 age- and BMI-matched females with normal glucose tolerance served as a control group. The diabetic patients were treated with cholecalciferol 1332 IU daily for one month. The mean plasma 25(OH)D level was 35.3±15.1 nmol/l at baseline, 70% of patients being vitamin D deficient. After one month of treatment with vitamin D₃, the plasma 25(OH)D level increased by a mean of 75.8%; 70% of the patients achieved normal vitamin D levels. FPIS increased significantly by 34.3%, while the change in SPIS of 20.4% was not significant (p>0.8). We found a significant correlation between the change in FPIS and the change in 25(OH)D level after vitamin D₃ supplementation (p<0.018). The results showed a decrease of 21.4% in insulin resistance after one month, but the change was not significant. Bearing in mind that the main defects in type 2 diabetes mellitus are reduced FPIS and insulin resistance, and the favourable effect vitamin D₃ had on them, we suggest vitamin D₃ deficiency may at least partly contribute to the impairment of insulin secretion and probably of insulin action. Our results suggest that vitamin D₃supplementation could be an element in the complex treatment of type 2 diabetes mellitus during the winter.

Revue / Journal Title

International journal of clinical practice   ISSN 1368-5031 

Source / Source

2003, vol. 57, n^o4, pp. 258-261 [4 page(s) (article)] (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1997) (Revue)

Mots-clés anglais / English Keywords

Endocrinopathy ; Quantitative analysis ; Endocrine secretion ; Hypoglycemic agent ; Treatment efficiency ; Adjuvant treatment ; Winter ; Supplementation ; Female ; Case control study ; Insulin ; Colecalciferol ; Biological effect ; Human ; Non insulin dependent diabetes ;

Mots-clés français / French Keywords

Endocrinopathie ; Résistance insuline ; Analyse quantitative ; Sécrétion endocrine ; Hypoglycémiant ; Efficacité traitement ; Traitement adjuvant ; Hiver ; Supplémentation ; Femelle ; Etude cas témoin ; Insuline ; Colécalciférol ; Effet biologique ; Homme ; Diabète non insulinodépendant ;

Mots-clés espagnols / Spanish Keywords

Endocrinopatía ; Análisis cuantitativo ; Secreción endocrina ; Hipoglicemiante ; Eficacia tratamiento ; Tratamiento adyuvante ; Invierno ; Suplementación ; Hembra ; Estudio caso control ; Insulina ; Colecalciferol ; Efecto biológico ; Hombre ; Diabetes no insulinodependiente ;

Localisation / Location

INIST-CNRS, Cote INIST : 15561, 35400011116887.0030