Titre du document / Document title

Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice

Auteur(s) / Author(s)

BANNAI Makoto ; YOSHIMOTO Ryo ; MITSUI-SAITO Minori ; HORI Masatoshi ; NISHIHARA Masugi ; TAKAHASHI Katsuhito ; YAMAMURA Hisako ; TANIGUCHI Shunichiro ; KATSUKI Motoya ; OZAKI Hiroshi ; KARAKI Hideaki ;

Résumé / Abstract

Calponin (h1 or basic) is an actin-binding protein that is expressed abundantly in smooth muscle. Our previous study using h1 calponin-null mutant mice demonstrated that h1 calponin inhibits the shortening velocity of smooth muscle contraction without significantly affecting the amplitude of force production. Furthermore, early onset of osteogenesis and increased bone formation have been reported in mutated mice. In the present study, we examined the effect of h 1 calponin depletion on the metabolism and behavior of mice and found that the mutated mice showed increased locomotor activity, as well as increased intake of food and water, associated with the decreased number of neurons in the paraventricular nucleus of the hypothalamus (PVN).

Revue / Journal Title

Journal of veterinary medical science   ISSN 0916-7250 

Source / Source

2003, vol. 65, n^o1, pp. 153-155 [3 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Japanese Society of Veterinary Science, Tokyo, JAPON  (1991) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 2347, 35400011818201.0290