Titre du document / Document title
Pulmonary function in fur-processing workers: A dose-response relationship
Auteur(s) / Author(s)
JIE CHEN (1) ;
JIEZHI LOU (1) ;
ZHENLIN LIU (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, CHINE
Résumé / Abstract
Pulmonary function tests were conducted in 212 male workers exposed to fur dust in a fur-processing factory, and in 148 unexposed male workers. The authors used the cumulative dose of dust exposure (mg-yr) as an exposure index to relate to pulmonary function injury, as measured by pulmonary function tests, in exposed workers. The results showed that fur workers had lower percentages of predicted pulmonary function, as measured by forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV
1.0), and maximal flow rate of expiration at 50% and 25% of forced vital capacity (V
50 and V
25, respectively), compared with controls (p < 0.01). As the cumulative dose of fur dust exposure increased, average levels of pulmonary function declined significantly (p < 0.01), and pulmonary function abnormalities (i.e., < 80% of predicted FVC and FEV
1.0, or < 70% of predicted V
50 and V
25) increased significantly (p < 0.05). Multiple-regression results identified fur dust exposure as the leading risk factor associated with the decline in pulmonary function in the exposed group. The results demonstrated a dose-response relationship between fur dust exposure and respiratory system injury, as measured by pulmonary function tests in fur-processing workers. On the basis of this dose-response relationship and the use of life-tables, the authors proposed an exposure limit of 4 mg/m
3 for fur dust.
Revue / Journal Title
Archives of environmental health
ISSN
0003-9896
CODEN AEHLAU
Source / Source
2003, vol. 58, n
o1, pp. 37-41 [5 page(s) (article)] (8 ref.)
Langue / Language
Anglais
Editeur / Publisher
Heldref, Washington, DC, ETATS-UNIS
(1960-2004)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 2784, 35400011801934.0050
Nº notice refdoc (ud4) : 14777753
