Titre du document / Document title

Scanning laser Doppler flowmetry of nonperfused regions of the optic nerve head in patients with glaucoma

Auteur(s) / Author(s)

BEN SIMON Guy J. ⁽¹⁾ ; MOROZ Iris ⁽¹⁾ ; GOLDENFELD Mordechai ⁽¹⁾ ; MELAMED Shlomo ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Goldschleger Eye Institute, Sheba Medical Center, Tel-Hashomer, ISRAEL

Résumé / Abstract

■ BACKGROUND AND OBJECTIVE: To examine the reliability of scanning laser Doppler flowmetry in measuring capillary flow in regions of the optic nerve head, which are manifested differently by confocal tomographic angiography. ■ PATIENTS AND METHODS: Capillary blood flow of the optic nerve head was measured in 16 eyes of 13 patients who had glaucoma with moderate to severe visual field defects. Blood flow measurements were taken by the scanning laser Doppler flowmeter and analyzed using the automatic full-field perfusion image analyzer (AFFPIA). Flow values were compared between perfused and nonperfused halves of the optic nerve head. Vascular anatomy of the optic nerve head was evaluated by confocal laser tomography with indocyanine green injection, and visual field tests by a standard visual field analyzer. ■ RESULTS: Analysis of laser capillary flow parameters by the AFFPIA disclosed a mean lower flow value in nonperfused compared with perfused discs (426 ± 310 vs 547 ± 306; P =.006). There was also a positive correlation between visual field defect and capillary angiography of the optic nerve head. ■ CONCLUSIONS: Flow measurements of the optic nerve head by scanning laser Doppler flowmetry using the AFFPIA revealed a mean lower flow value in nonperfused discs of patients who had glaucoma with severe visual field defect. Capillary angiography demonstrated by Heidelberg retina angiography has a good correlation with the pattern of visual field defect.

Revue / Journal Title

Ophthalmic surgery, lasers & imaging   ISSN 1542-8877 

Source / Source

2003, vol. 34, n^o3, pp. 245-250 [6 page(s) (article)] (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Slack, Thorofare, NJ, ETATS-UNIS  (2003) (Revue)

Mots-clés anglais / English Keywords

Eye disease ; Human ; Capillary flow ; Hemodynamics ; Optic nerve ; Head ; Scanning ; Laser ; Doppler ultrasound study ; Flowmetry ; Reliability ; Exploration ; Glaucoma (eye) ;

Mots-clés français / French Keywords

Oeil pathologie ; Homme ; Ecoulement capillaire ; Hémodynamique ; Nerf optique ; Tête ; Balayage ; Laser ; Dopplérométrie ; Débitmétrie ; Fiabilité ; Exploration ; Glaucome ;

Mots-clés espagnols / Spanish Keywords

Ojo patología ; Hombre ; Flujo capilar ; Hemodinámica ; Nervio óptico ; Cabeza ; Exploración ; Laser ; Dopplerometría ; Caudalimetría ; Fiabilidad ; Exploración ; Glaucoma (ojo) ;

Localisation / Location

INIST-CNRS, Cote INIST : 14946, 35400011811362.0170