Titre du document / Document title

Y chromosome haplogroups: A correlation with testicular dysgenesis syndrome? Commentaries

Auteur(s) / Author(s)

MCELREAVEY Ken ⁽¹⁾ ; QUINTANA-MURCI Lluis ⁽¹⁾ ; VON EYBEN Finn Edler (Commentateur) ; GIWERCMAN Yvonne (Commentateur) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Reproduction, Fertility and Populations, Institut Pasteur, Paris, FRANCE

Résumé / Abstract

Testicular dysgenesis syndrome encompasses low sperm quality, hypospadias, cryptorchidism and testicular cancer. Epidemiological studies and genetic data from familial cases suggest that testicular dysgenesis syndrome has a common etiology. The Y chromosome is known to encode genes that are involved in germ cell development or maintenance. We have therefore investigated if different classes of Y chromosomes in the general population (Y chromosome haplogroups) are associated with aspects of the testicular dysgenesis syndrome. We defined the Y chromosome haplogroups in individuals from different European counties who presented with either (i) oligo- or azoospermia associated with a Y chromosome microdeletion, (ii) unexplained reduced sperm counts (<20×10⁶/ml) or (iii) testicular cancer. We failed to find Y chromosome haplotype associations with either microdeletion formation or testicular cancer. However, in a study of the Danish population, we found that a specific Y chromosome haplogroup (hg26) is significantly overrepresented in men with unexplained reduced sperm counts compared with a Danish control population. The factors encoded by genes on this class of Y chromosome may be particularly susceptible to environmental influences that cause testicular dysgenesis syndrome. Our current data highlight the need for further analyses of clinically well-defined patient groups from a wide range of ethnic and geographic origins.

Revue / Journal Title

APMIS. Acta pathologica, microbiologica et immunologica Scandinavica   ISSN 0903-4641 

Source / Source

Congrès
Copenhagen Workshop on Carcinoma in situ and Cancer of the Testis: Environmental and Genetic Aspects N^o5, Copenhagen , DANEMARK (29/08/2002)
2003, vol. 111, n^o 1 (292 p.)  [Document : 9 p.] (38 ref.), pp. 106-114 [9 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1988) (Revue)

Mots-clés anglais / English Keywords

Microbiology ;

Mots-clés français / French Keywords

Microbiologie ;

Mots-clés espagnols / Spanish Keywords

Microbiología ;

Localisation / Location

INIST-CNRS, Cote INIST : 948, 35400011097467.0130