Titre du document / Document title

Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in Bipolar disorder

Auteur(s) / Author(s)

FRYE Mark A. ; ALTSHULER Lori L. ; MCELROY Susan L. ; SUPPES Trisha ; KECK Paul E. ; DENICOFF Kirk ; NOLEN Willem A. ; KUPKA Ralph ; LEVERICH Gabriele S. ; POLLIO Chad ; GRUNZE Heinz ; WALDEN Jorge ; POST Robert M. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Department of Psychiatry and Biohehavioral Sciences, University of California, School of Medicine, Los Angeles, ETATS-UNIS
Department of Biological Psychiatry, University of Cincinnati School of Medicine, Cincinnati, ETATS-UNIS
Department of Psychiatry, University of Texas Southwestern, Dallas, ETATS-UNIS
Biological Psychiatry Branch, NIMH, Bethesda, Md., ETATS-UNIS
Altrecht Institute for Mental Health Care, University Medical Center, Utrecht, PAYS-BAS
Psychiatrische Klinik de Ludwig-Maximilian Universität, Munich, ALLEMAGNE
Universitatsklinik für Psychiatrie der Universität Freiburg, Freiburg, ALLEMAGNE

Résumé / Abstract

Objective: The prevalence of lifetime alcohol abuse and/or dependence (alcoholism) in patients with bipolar disorder has been reported to be higher than in all other axis I psychiatric diagnoses. This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study. Method: The prevalence of lifetime alcoholism in 267 outpatients enrolled in the Stanley Foundation Bipolar Network was evaluated by using the Structured Clinical Interview for DSM-IV. Alcoholism and its relationship to retrospectively assessed measures of the course of bipolar illness were evaluated by patient-rated and clinician-administered questionnaires. Results: As in the general population. more men (49%, 57 of 116) than women with bipolar disorder (29%, 44 of 151) met the criteria for lifetime alcoholism. However, the risk of having alcoholism was greater for women with bipolar disorder (odds ratio=7.35) than for men with bipolar disorder (odds ratio=2.77), compared with the general population. Alcoholism was associated with a history of polysubstance use in women with bipolar disorder and with a family history of alcoholism in men with bipolar disorder. Conclusions: This study suggests that there are gender differences in the prevalence, risk, and clinical correlates of alcoholism in bipolar illness. Although this study is limited by the retrospective assessment of illness variables, the magnitude of these gender-specific differences is substantial and warrants further prospective study.

Revue / Journal Title

The American journal of psychiatry   ISSN 0002-953X   CODEN AJPSAO 

Source / Source

2003, vol. 160, n^o5, pp. 883-889 [7 page(s) (article)] (40 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Psychiatric Association, Washington, DC, ETATS-UNIS  (1921) (Revue)

Mots-clés anglais / English Keywords

Addiction ; Mood disorder ; Human ; Retrospective ; Predictive factor ; Sex ; Diagnosis ; Subtype ; Comparative study ; Alcoholism ; Dependence ; Abuse ; Alcoholic beverage ; Concomitant disease ; Risk factor ; Prevalence ; Bipolar disorder ;

Mots-clés français / French Keywords

Addiction ; Trouble humeur ; Homme ; Rétrospective ; Facteur prédictif ; Sexe ; Diagnostic ; Soustype ; Etude comparative ; Alcoolisme ; Dépendance ; Abus ; Boisson alcoolisée ; Association morbide ; Facteur risque ; Prévalence ; Trouble bipolaire ;

Mots-clés espagnols / Spanish Keywords

Adicción ; Trastorno humor ; Hombre ; Retrospectiva ; Factor predictivo ; Sexo ; Diagnóstico ; Subtipo ; Estudio comparativo ; Alcoholismo ; Dependencia ; Abuso ; Bebida alcohólica ; Asociación morbosa ; Factor riesgo ; Prevalencia ; Trastorno bipolar ;

Localisation / Location

INIST-CNRS, Cote INIST : 3283, 35400011805141.0110