Titre du document / Document title

Survey of high- and low-level mupirocin-resistant strains of methicillin-resistant Staphylococcus aureus in 15 Japanese hospitals

Auteur(s) / Author(s)

FUJIMURA Shigeru ^{(1 2)} ; WATANABE Akira ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Departments of Microbiology, Miyagi University, Miyagi, JAPON
⁽²⁾ Respiratory Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JAPON

Résumé / Abstract

Background: The extent of mupirocin-resistant methicillin-resistant Staphylococcus aureus (MRSA) in countries using mupirocin only for the eradication of nasal carriage of MRSA is unknown. Methods: During 1997, 1998, 1999, 2000, and 2001, 1,368 strains of MRSA were isolated from 15 general hospitals in the Tohoku area of Japan and tested for susceptibility to mupirocin. Results: The isolation of low-level mupirocin resistance was 0.8% in 1997, 1.1% in 1998, 0.7% in 1999, 4.0% in 2000, and 2.4% in 2001. For the first 3 years it was about 1%. However, the isolation rate of low-level mupirocin resistance in MRSA increased dramatically in 2000. High-level mupirocin resistance was not detected during these years. Conclusion: Most patients from whom low-level mupirocin resistant MRSA were found in 2000 and 2001 had previously received mupirocin treatment for eradicating nasal carriage of MRSA, and these strains were isolated from sputum or the pharynx. This result indicates that mupirocin treatment is likely to be one of the causes of mupirocin resistance and, therefore, the development of low-level mupirocin resistance in MRSA isolated from sputum or the pharynx should be considered when using mupirocin in order to improve the control of the spread of MRSA in hospitals.

Revue / Journal Title

Chemotherapy   ISSN 0009-3157   CODEN CHTHBK 

Source / Source

2003, vol. 49, n^o1-2, pp. 36-38 [3 page(s) (article)] (10 ref.)

Langue / Language

Anglais

Editeur / Publisher

Karger, Basel, SUISSE  (1968) (Revue)

Mots-clés anglais / English Keywords

Asia ; Bacteria ; Micrococcales ; Micrococcaceae ; β-Lactams ; Penicillin derivatives ; Prevalence ; Isolate ; Hospital ; Japan ; Human ; Infection ; Survey ; Pathogen strain ; Treatment resistance ; Antibacterial agent ; Antibiotic ; Mupirocin ; Meticillin ; Epidemiology ; Staphylococcus aureus ;

Mots-clés français / French Keywords

Asie ; Bactérie ; Micrococcales ; Micrococcaceae ; β-Lactamines ; Pénicilline dérivé ; Prévalence ; Isolat ; Hôpital ; Japon ; Homme ; Infection ; Enquête ; Souche pathogène ; Résistance traitement ; Antibactérien ; Antibiotique ; Mupirocine ; Méticilline ; Epidémiologie ; Staphylococcus aureus ;

Mots-clés espagnols / Spanish Keywords

Asia ; Bacteria ; Micrococcales ; Micrococcaceae ; β-Lactams ; Penicilinas ; Prevalencia ; Aislado ; Hospital ; Japón ; Hombre ; Infección ; Encuesta ; Cepa patógena ; Resistencia tratamiento ; Antibacteriano ; Antibiótico ; Mupirocina ; Meticilina ; Epidemiología ; Staphylococcus aureus ;

Mots-clés d'auteur / Author Keywords

Mupirocin ; Methicillin-resistant Staphylococcus aureus ; Low-level resistance ; Surveillance ; Japan ;

Localisation / Location

INIST-CNRS, Cote INIST : 1189, 35400011808970.0070