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Titre du document / Document title

Sedation and plasma concentration of clonidine hydrochloride for pre-anesthetic medication in pediatric surgery

Auteur(s) / Author(s)

SUMIYA Kenji (1) ; HOMMA Masato (2) ; WATANABE Machiko (1) ; BABA Yasuyuki (1) ; INOMATA Shin-Ichi (3) ; KIHARA Shin-Ichi (3) ; TOYOOKA Hidenori (3) ; KOHDA Yukinao (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmacy, Tsukuba University Hospital, Tsukuba, Ibaraki 305-8576, JAPON
(2) Department of Pharmaceutical Sciences, Institute of Clinical Medicine, University of Tsukuha, JAPON
(3) Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Iharaki 305 8575, JAPON

Résumé / Abstract

Clonidine hydrochloride has been used for pre-anesthetic medication to provide a pre-operative sedation in pediatric surgery. The purpose of this study is to determine the plasma clonidine concentration, which gives satisfactory sedation in pediatric surgery. Sixteen pediatric patients (age: 1-11 years, weight: 9-33 kg) received either 2 or 4 μg/kg of clonidine lollipop before entering the operating room. Plasma clonidine concentrations were determined 120 min after administration of clonidine lollipop. Pre-operative sedation was evaluated by 5-point scoring systems at entering the operating room. The changes in systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were also assessed before and after administration of clonidine lollipop. The patients with satisfactory sedation had higher plasma clonidine concentration than that of the patients with unsatisfactory sedation (0.45±0.16 ng/ml vs. 0.26±0.16 ng/ml, p<0.05). The clonidine concentrations in the satisfactory group ranged from 0.28 to 0.81 nglml. There was no significant difference in hemodynamic parameters (SBP, DBP and HR) before and after administration of clonidine lollipop in both satisfactory and unsatisfactory sedation groups. Plasma clonidine concentration of 0.3-0.8 ng/ml would be sufficient to produce satisfactory sedation without changes in hemodynamic parameters in pediatric surgery.

Revue / Journal Title

Biological & pharmaceutical bulletin    ISSN  0918-6158 

Source / Source

2003, vol. 26, no4, pp. 421-423 [3 page(s) (article)] (14 ref.)

Langue / Language


Editeur / Publisher

Pharmaceutical Society of Japan, Tokyo, JAPON  (1993) (Revue)

Mots-clés d'auteur / Author Keywords

plasma clonidine concentration




pre-anesthetic sedation


Localisation / Location

INIST-CNRS, Cote INIST : 18096, 35400011947802.0050

Nº notice refdoc (ud4) : 14736052

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