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Titre du document / Document title

Anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with juvenile idiopathic arthritis

Auteur(s) / Author(s)

VAN ROSSUM Marion ; VAN SOESBERGEN Renee ; DE KORT Sandra ; TEN CATE Rebecca ; ZWINDERMAN Aeilko H. ; DE JONG B. E. N. ; DIJKMANS Ben ; VAN VENROOIJ Walther J. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Department of Pediatrics, Leiden University Medical Center, Leiden, PAYS-BAS
Department of Rheumatology, Slotervaart Hospital, Amsterdam, PAYS-BAS
Department of Rheumatology, Jan van Breemen Instituut, Amsterdam, PAYS-BAS
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, PAYS-BAS
Department of Rheumatology, VU University Medical Center, Amsterdam, PAYS-BAS
Department of Biochemistry 161, NCMLS, University of Nijmegen, Nijmegen, PAYS-BAS

Résumé / Abstract

Objective. To determine if anti-cyclic citrullinated peptide antibodies (anti-CCP) can be detected in sera of patients with juvenile idiopathic arthritis (JIA) and if they can be used to identify patients with a more destructive course of disease. Methods. One hundred serum samples of 71 patients with JIA taken at different time points in their disease course were analyzed by a commercially available anti-CCP ELISA. Followup serum samples from 28 patients were also tested. Correlations between anti-CCP and disease characteristics, medication, and radiological damage (presence of joint space narrowing and/or erosions) were also determined. Results. The serum samples came from patients of all 8 different subtypes of JIA (mean age: 9.6 years, median: 10.5; disease duration mean: 39 months, median: 24) including 11 polyarticular rheumatoid factor positive (IgM-RF) patients. Anti-CCP was positive in 73% of the IgM-RF positive JIA patients and in 3% of the other JIA patients (p < 0.0001 Disease duration, medication, and anti-nuclear antibody positivity did not differ significantly between anti-CCP positive and negative patients. Testing of followup samples showed almost identical anti-CCP results. All IgM-RF positive JIA patients had radiological damage (p < 0.001). Of the anti-CCP positive patients, 80% had radiological damage resulting in a significant difference between anti-CCP positive and negative patients (p = 0.009) with an odds ratio (OR) of 12.7, but corrected for IgM-RF, the OR was no longer significant (p = 0.88). Conclusion. Anti-CCP antibodies can be detected in the sera of patients with JIA but almost exclusively in the subset of patients with polyarticular IgM-RF.

Revue / Journal Title

Journal of rheumatology    ISSN  0315-162X   CODEN JRHUA9 

Source / Source

2003, vol. 30, no4, pp. 825-828 [4 page(s) (article)] (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Journal of Rheumatology Publishing, Toronto, ON, CANADA  (1974) (Revue)

Mots-clés anglais / English Keywords

Antibody

;

Inflammatory joint disease

;

Diseases of the osteoarticular system

;

Human

;

Chronic

;

ELISA assay

;

Serum

;

Citrulline

;

Cyclic peptides

;

Autoantibody

;

Rheumatoid factor

;

Pathogenesis

;

Humoral immunity

;

Autoimmunity

;

Child

;

Juvenile rheumatoid arthritis

;

Mots-clés français / French Keywords

Anticorps

;

Rhumatisme inflammatoire

;

Système ostéoarticulaire pathologie

;

Homme

;

Chronique

;

Technique ELISA

;

Sérum

;

Citrulline

;

Peptide cyclique

;

Autoanticorps

;

Facteur rhumatoïde

;

Pathogénie

;

Immunité humorale

;

Autoimmunité

;

Enfant

;

Arthrite chronique juvénile

;

Mots-clés espagnols / Spanish Keywords

Anticuerpo

;

Reumatismo inflamatorio

;

Sistema osteoarticular patología

;

Hombre

;

Crónico

;

Técnica ELISA

;

Suero

;

Citrulina

;

Péptido cíclico

;

Autoanticuerpo

;

Factor reumatoide

;

Patogenia

;

Inmunidad humoral

;

Autoinmunidad

;

Niño

;

Artritis crónica juvenil

;

Localisation / Location

INIST-CNRS, Cote INIST : 16024, 35400010997634.0300

Nº notice refdoc (ud4) : 14711218



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