Titre du document / Document title

Long-term effects of Topical cyclosporine A treatment after penetrating keratoplasty

Auteur(s) / Author(s)

INOUE K. ⁽¹⁾ ; AMANO S. ⁽²⁾ ; KIMURA C. ⁽²⁾ ; SATO T. ⁽²⁾ ; FUJITA N. ⁽²⁾ ; KAGAYA F. ⁽²⁾ ; KAJI Y. ⁽²⁾ ; OSHIKA T. ⁽³⁾ ; TSURU T. ⁽⁴⁾ ; ARAIE M. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Ophthalmology, Branch Hospital University of Tokyo School of Medicine, Tokyo, JAPON
⁽²⁾ Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, JAPON
⁽³⁾ Section of Corneal Transplantation, University Hospital, University of Tokyo School of Medicine, Tokyo, JAPON
⁽⁴⁾ Department of Ophthalmology, Jichi Medical School, Tochigi Prefecture, JAPON

Résumé / Abstract

Purpose: To evaluate the long-term outcome of topical 2% cyclosporine A (CsA) treatment as an adjunct to topical corticosteroid treatment of patients after penetrating keratoplasty (PKP). Methods: We reviewed the records of 83 patients (86 eyes) who had undergone PKP and received topical CsA treatment postoperatively; also the records of 95 PKP patients (97 eyes) who received the same treatment, except for the 2% CsA eyedrops, and served as controls. The patients were also subdivided into high-risk and low-risk groups. The clinical outcome of PKP was evaluated by the rates of graft survival and rejection-free graft survival, using the Kaplan-Meier method, and compared with the logrank test. Results: In the high-risk patients, the rejection-free graft survival rate was 69.7% in the CsA group and 45.4% in the control group (P = .030), but there was no significant difference in the graft survival rate between the two groups. Conclusion: Topical cyclosporine treatment is effective in reducing the risk of allograft rejection in high-risk patients.

Revue / Journal Title

Japanese journal of ophthalmology   ISSN 0021-5155   CODEN JJOPA7 

Source / Source

2000, vol. 44, n^o3, pp. 302-305 (5 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1957) (Revue)

Mots-clés anglais / English Keywords

Keratoplasty ; Penetrating graft ; Ciclosporin ; Immunosuppressive agent ; Chemoprophylaxis ; Treatment ; Prevention ; Graft versus host reaction ; Local administration ; Treatment efficiency ; Long term ; Human ; Surgery ; Eye disease ;

Mots-clés français / French Keywords

Kératoplastie ; Greffe transfixiante ; Ciclosporine ; Immunodépresseur ; Chimioprophylaxie ; Traitement ; Prévention ; Maladie greffon hôte ; Voie locale ; Efficacité traitement ; Long terme ; Homme ; Chirurgie ; Oeil pathologie ;

Mots-clés espagnols / Spanish Keywords

Queratoplastia ; Injerto penetrante ; Ciclosporina ; Inmunodepresor ; Quimioprofilaxis ; Tratamiento ; Prevención ; Enfermedad injerto huesped ; Vía local ; Eficacia tratamiento ; Largo plazo ; Hombre ; Cirugía ; Ojo patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 10390, 35400009146516.0170