Titre du document / Document title

Misoprostol induces relaxation of human corpus cavernosum smooth muscle: comparison to prostaglandin E1

Auteur(s) / Author(s)

MORELAND R. B. ⁽¹⁾ ; KIM N. N. ⁽¹⁾ ; NEHRA A. ⁽²⁾ ; PARULKAR B. G. ⁽³⁾ ; TRAISH A. ^{(1 4)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Urology, Boston University School of Medicine, Boston, MA 02118, ETATS-UNIS
⁽²⁾ Department of Urology, Mayo Clinic and Foundation, Rochester, MN 55905, ETATS-UNIS
⁽³⁾ Department of Urology, University of Massachusetts Medical Center, Worcester, MA 01604, ETATS-UNIS
⁽⁴⁾ Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, ETATS-UNIS

Résumé / Abstract

Prostaglandin E1 (PGE1) relaxes trabecular smooth muscle by interacting with specific G-protein coupled receptors on human corpus cavernosum smooth muscle and increasing intracellular synthesis of cAMP. Misoprostol (Cytotec), is an oral prostaglandin E analogue. The purpose of this study was to compare the functional activity of misoprostol with PGE1 in human corpus cavernosum and cultured human corpus cavernosum smooth muscle cells. Misoprostol, misoprostol free acid or PGE1 induced dose-dependent relaxations in strips of human corpus cavernosum. At concentrations greater than 10^-6M, tissue recontraction was observed with all three agents. This was abrogated by pretreatment with the thromboxane A2 receptor antagonist SQ29,548. From these observations, we conclude that misoprostol is activated by human corpus cavernosum in situ and relaxes phenylephrine-precontrated tissue strips in vitro. This relaxation response is mediated by the increased cAMP synthesis by these agents.

Revue / Journal Title

International journal of impotence research   ISSN 0955-9930 

Source / Source

2000, vol. 12, n^o2, pp. 107-110 (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing, Basingstoke, ROYAUME-UNI  (1989) (Revue)

Mots-clés anglais / English Keywords

Misoprostol ; Biological effect ; Corpus cavernosum ; Prostaglandin derivatives ; Cyclic AMP ; Smooth muscle ; Erection ; Comparative study ; Human ; Male ;

Mots-clés français / French Keywords

Misoprostol ; Effet biologique ; Corps caverneux ; Prostaglandine dérivé ; AMP cyclique ; Muscle lisse ; Erection ; Etude comparative ; Homme ; Mâle ;

Mots-clés espagnols / Spanish Keywords

Misoprostol ; Efecto biológico ; Cuerpo cavernoso ; Prostaglandina derivado ; AMP cíclico ; Músculo liso ; Erección ; Estudio comparativo ; Hombre ; Macho ;

Localisation / Location

INIST-CNRS, Cote INIST : 26573, 35400009191918.0050