Titre du document / Document title

Plasma concentrations of asymmetric-dimethyl-arginine in type 2 diabetes associate with glycemic control and glomerular filtration rate but not with risk factors of vasculopathy

Auteur(s) / Author(s)

PÄIVÄ Hannu ; LEHTIMÄKI Terho ; LAAKSO Juha ; RUOKONEN Inkeri ; RANTALAIHO Vappu ; WIRTA Ole ; PASTERNACK Amos ; LAAKSONEN Reijo ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Department of Internal Medicine, Tampere University Hospital, Tampere, FINLANDE
Department of Clinical Pharmacology, University of Helsinki, Helsinki, FINLANDE
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and University of Tampere, Medical School, Tampere, FINLANDE

Résumé / Abstract

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). Increased plasma levels of ADMA may indicate endothelial dysfunction and increased risk of angiopathy. The relation of ADMA to diabetes, glycemic control, and renal function, especially early diabetic hyperfiltration, remains unknown. We tried to evaluate whether there is an association between ADMA and glycosylated hemoglobin (GHbA_ic) on the one hand and glomerular filtration rate (GFR) on the other hand in diabetic subjects with normal or slightly increased GFR. We also studied whether plasma ADMA is associated with some risk factors of vasculopathy (hypercholesterolemia and hypertension). The study subjects consisted of 86 patients with type 2 diabetes and 65 control subjects. Plasma ADMA levels were measured by high-pressure liquid chromatography as o-pthalaldehyde (OPA) derivatives and GFR was determined by the plasma clearance of chromium 51-EDTA. The diabetic patients had lower plasma ADMA levels than the nondiabetic control subjects (0.29 ± 0.15 v 0.34 ± 0.16 μmol/L, P <.03). In the diabetic subjects, plasma ADMA concentrations were inversely correlated with GHbA,_1c (R = -0.28, P =.01). In a multivariate linear model, significant predictors of ADMA were GFR (R = -0.32, P =.008) in diabetic subjects and GHbA_1c (R = -0.19, P =.03) and GFR (R = -0.19, P =.02) in all subjects. Plasma ADMA was not associated with risk factors of vasculopathy. We conclude that diabetic patients with a normal or slightly increased GFR have lower circulating ADMA concentrations than nondiabetic control subjects. In type 2 diabetic patients high GFR and poor glycemic control were related to low plasma ADMA concentrations.

Revue / Journal Title

Metabolism, clinical and experimental   ISSN 0026-0495 

Source / Source

2003, vol. 52, n^o3, pp. 303-307 [5 page(s) (article)] (38 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1952) (Revue)

Mots-clés anglais / English Keywords

Urinary system disease ; Endocrinopathy ; Enzyme ; Oxidoreductases ; Kidney disease ; Cardiovascular disease ; Hemoglobin A1c ; Renal function ; Glomerular filtration ; Glycemia ; Comparative study ; Blood plasma ; Arginine ; Nitric-oxide synthase ; Enzyme inhibitor ; Pathogenesis ; Complication ; Non insulin dependent diabetes ;

Mots-clés français / French Keywords

Appareil urinaire pathologie ; Endocrinopathie ; Enzyme ; Oxidoreductases ; Diméthylarginine ; Rein pathologie ; Appareil circulatoire pathologie ; Hémoglobine A1c ; Fonction rénale ; Filtration glomérulaire ; Glycémie ; Etude comparative ; Plasma sanguin ; Arginine ; Nitric-oxide synthase ; Inhibiteur enzyme ; Pathogénie ; Complication ; Diabète non insulinodépendant ;

Mots-clés espagnols / Spanish Keywords

Aparato urinario patología ; Endocrinopatía ; Enzima ; Oxidoreductases ; Riñón patología ; Aparato circulatorio patología ; Hemoglobina A1c ; Función renal ; Filtración glomerular ; Glucemia ; Estudio comparativo ; Plasma sanguíneo ; Arginina ; Nitric-oxide synthase ; Inhibidor enzima ; Patogenia ; Complicación ; Diabetes no insulinodependiente ;

Localisation / Location

INIST-CNRS, Cote INIST : 6965, 35400010956465.0080