Titre du document / Document title

Common herbs, essential oils, and monoterpenes potently modulate bone metabolism

Auteur(s) / Author(s)

MÜHLBAUER R. C. ⁽¹⁾ ; LOZANO A. ⁽¹⁾ ; PALACIO S. ⁽¹⁾ ; REINLI A. ⁽¹⁾ ; FELIX R. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Bone Biology Group, Department of Clinical Research, University of Bern, Murtenstrasse 35, 3010 Bern, SUISSE

Résumé / Abstract

During our survey of herbs looking for activity on bone metabolism, we found that the dried leaves of sage strongly inhibit bone resorption. Therefore, we investigated several common herbs rich in essential oils ( sage, rosemary, and thyme) and essential oils extracted from these herbs and other plants (oils of sage, rosemary, juniper, pine, dwarf pine, turpentine, and eucalyptus) as well as their monoterpene components (thujone. eucalyptol, camphor, borneol, thymol, α-pinene, β-pinene, bornylacetate as well as menthol) and found that they inhibit bone resorption when added to the food of rats. Pine oil, used as a representative essential oil, protects an osteoporosis model, the aged ovariectomized rat, from bone loss. The monoterpenes borneol, thymol, and camphor are directly inhibitory in the osteoclast resorption pit assay. Nonpolar monoterpenes may require metabolism to be active in vitro, for example, cis-verbenol, a metabolite of α-pinene occurring in human urine, inhibits osteoclast activity in contrast to the parent compound. Within 30 min borneol inhibits the formation of actin rings, a characteristic of resorbing osteoclasts indicating cell polarization. Both the in vitro and the in vivo effects of borneol are reversible. Our study demonstrates for the first time that essential oils and monoterpenes are efficient inhibitors of bone resorption in the rat.

Revue / Journal Title

Bone   ISSN 8756-3282 

Source / Source

2003, vol. 32, n^o4, pp. 372-380 [9 page(s) (article)] (41 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1985) (Revue)

Mots-clés anglais / English Keywords

Vertebrata ; Mammalia ; Rodentia ; Rat ; Animal ; Experimental study ; Treatment ; Aromatherapy ; Inhibition ; Bone ; Resorption ; Biological activity ; Feeding ; Flavoring crop ; Monoterpene ; Medicinal plant ; Essential oil ;

Mots-clés français / French Keywords

Vertebrata ; Mammalia ; Rodentia ; Rat ; Animal ; Etude expérimentale ; Traitement ; Aromathérapie ; Inhibition ; Os ; Résorption ; Activité biologique ; Alimentation ; Plante condimentaire ; Monoterpène ; Plante médicinale ; Huile essentielle ;

Mots-clés espagnols / Spanish Keywords

Vertebrata ; Mammalia ; Rodentia ; Rata ; Animal ; Estudio experimental ; Tratamiento ; Aromaterapia ; Inhibición ; Hueso ; Resorción ; Actividad biológica ; Alimentación ; Planta condimentaria ; Monoterpeno ; Planta medicinal ; Aceite esencial ;

Mots-clés d'auteur / Author Keywords

Bone resorption ; Osteoporosis ; Monoterpenes ; Essential oils ; Plant ; Rat ;

Localisation / Location

INIST-CNRS, Cote INIST : 19041, 35400010993377.0070