Titre du document / Document title

Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress: A randomized controlled trial

Auteur(s) / Author(s)

AGHDASSI Elaheh ; WENDLAND Barbara E. ; STEINHART A. Hillary ; WOLMAN Stephen L. ; JEEJEEBHOY Khursheed ; ALLARD Johane P. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Gastroenterology and Nutrition Research, Department of Medicine, Toronto General Hospital, University Health Network, Toronto, Ontario, ETATS-UNIS
Division of Gastroenterology, Mount Sinai Hospital, Toronto, Ontario, CANADA
Division of Gastroenterology, St. Michael Hospital, University of Toronto, Toronto, Ontario, CANADA

Résumé / Abstract

OBJECTIVE: We showed previously that patients with Crohn's disease (CD) had increased oxidative stress and lower antioxidant vitamins compared with healthy controls. This is despite inactive or mildly active disease and maintenance therapy. The aim of this study was to evaluate in these patients the effects of antioxidant vitamin supplementation on oxidative stress. METHODS: This is a randomized controlled trial where stable but oxidatively stressed CD subjects (n = 57) were supplemented with vitamins E (800 IU) and C (1000 mg) or their placebo for 4 wk. Oxidative stress measured by breath pentane and ethane output, plasma lipid peroxides, and F2-isoprostane was assessed at baseline and at 4 wk. Disease activity was also monitored by measuring CD activity index and plasma orosomucoid. RESULTS: During supplementation, plasma vitamin C and α-tocopherol increased and all indices of oxidative stress decreased significantly. Disease activity remained stable. CONCLUSIONS: In this population, vitamin E and C supplementation resulted in a significant reduction in oxidative stress. This suggests that patients with inactive or mildly active CD can be oxidatively stressed and have increased requirement in antioxidant vitamins.

Revue / Journal Title

The American journal of gastroenterology   ISSN 0002-9270 

Source / Source

2003, vol. 98, n^o2, pp. 348-353 [6 page(s) (article)] (48 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell Publishing, Oxford, ROYAUME-UNI  (1954) (Revue)

Mots-clés anglais / English Keywords

Chemotherapy ; Inflammatory disease ; Intestinal disease ; Digestive diseases ; Human ; Randomization ; Clinical trial ; Ascorbic acid ; E-Vitamins ; Antioxidant ; Supplementation ; Biological activity ; Oxidative stress ; Crohn disease ;

Mots-clés français / French Keywords

Chimiothérapie ; Maladie inflammatoire ; Intestin pathologie ; Appareil digestif pathologie ; Homme ; Randomisation ; Essai clinique ; Acide ascorbique ; Vitamine E ; Antioxydant ; Supplémentation ; Activité biologique ; Stress oxydatif ; Entérite Crohn ;

Mots-clés espagnols / Spanish Keywords

Quimioterapia ; Enfermedad inflamatoria ; Intestino patología ; Aparato digestivo patología ; Hombre ; Aleatorización ; Ensayo clínico ; Acido ascórbico ; Vitamina E ; Antioxidante ; Suplementación ; Actividad biológica ; Estrés oxidativo ; Enteritis Crohn ;

Localisation / Location

INIST-CNRS, Cote INIST : 11062, 35400010424225.0210