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Titre du document / Document title

Oral isotretinoin as part of the treatment of cutaneous aging

Auteur(s) / Author(s)

HERNANDEZ-PEREZ E. (1) ; HASSAN ABBAS KHAWAJA (1) ; TELMA YANET MEDA ALVAREZ (1) ; MD (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Center for Dermatology and Cosmetic Surgery, San Salvador, EL SALVADOR

Résumé / Abstract

BACKGROUND. A number of drugs have been used to prevent aging changes. However, studies of oral isotretinoin, the commonly used acne drug, as an antiaging drug are lacking. OBJECTIVE. To determine improvement in cutaneous aging utilizing oral isotretinoin combined with different procedures of facial rejuvenation. METHODS. Sixty patients ranging in age from 35 to 65 years, in whom additional modalities of rejuvenation were also used, were randomly assigned to receive treatment with oral isotretinoin (10-20 mg three times a week for 2 months, group A). Their results were compared with 60 patients who had undergone the same surgical procedures but with no oral isotretinoin (group B). RESULTS. All patients treated with oral isotretinoin noted improvement in wrinkles, thickness and color of the skin, size of pores, skin elasticity, tone, and reduction in pigmented lesions and mottled hyperpigmentation. A statistically significant difference was found in the improvement of group A (Wilcoxon test <0.01). Using minimal amounts of this drug, the side effects were practically negligible. CONCLUSION. Utilizing various procedures with oral isotretinoin allowed us to improve the effects of cutaneous aging. Our results using isotretinoin in these cases have been satisfactory. We believe that this is one of the first reports of the use of oral isotretinoin in intrinsic and photoaged skin.

Revue / Journal Title

Dermatologic surgery    ISSN  1076-0512 

Source / Source

2000, vol. 26, no7, pp. 649-652 (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Malden, MA, ETATS-UNIS  (1995) (Revue)

Mots-clés anglais / English Keywords

Isotretinoin

;

Treatment

;

Oral administration

;

Ageing

;

Skin

;

Human

;

Chemotherapy

;

Retinoid

;

Skin disease

;

Mots-clés français / French Keywords

Isotrétinoïne

;

Traitement

;

Voie orale

;

Vieillissement

;

Peau

;

Homme

;

Chimiothérapie

;

Rétinoïde

;

Peau pathologie

;

Mots-clés espagnols / Spanish Keywords

Isotretinoína

;

Tratamiento

;

Vía oral

;

Envejecimiento

;

Piel

;

Hombre

;

Quimioterapia

;

Retinoide

;

Piel patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 17417, 35400009037293.0080

Nº notice refdoc (ud4) : 1460661



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