Titre du document / Document title

Interaction between naltrexone and oral THC in heavy marijuana smokers

Auteur(s) / Author(s)

HANEY Margaret ⁽¹⁾ ; BISAGA Adam ⁽¹⁾ ; FOLTIN Richard W. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, ETATS-UNIS

Résumé / Abstract

Rationale: Studies in non-human animals suggest that opioid antagonists block the reinforcing effects of cannabinoids. Objective: The present studies in humans investigated how naltrexone modulates (1) the subjective and physiological effects of oral THC in comparison to methadone, (2) the reinforcing effects of oral THC, and (3) plasma levels of oral THC. Methods: In study 1, marijuana smokers (n=9) received naltrexone (0, 50 mg) followed 30 min later by THC (0, 15, 30 mg) or methadone (5, 10 mg). Subjective effects, task performance, pupillary diameter, and cardiovascular parameters were measured repeatedly. In study 2a, marijuana smokers (n=23) were randomly assigned to one THC dose condition (0, 15 or 30 mg). One set of color-coded capsules containing THC and active naltrexone (50 mg) was given in one session, while another set of color-coded capsules containing THC and placebo naltrexone was given in another session. In the final three sessions, participants chose which color capsules they would receive. In study 2b, a subset of participants from study 2a (n=7) received naltrexone (0, 50 mg) 30 min prior to oral THC (30 mg) administration, and blood was drawn repeatedly. Results: Pretreatment with naltrexone significantly increased many of the positive subjective effects of oral THC (30 mg) e.g. ratings of Good Drug Effect and Capsule Liking. Naltrexone tended to increase the reinforcing effects of oral THC (30 mg), as indicated by performance in a drug choice test. Naltrexone did not alter plasma THC levels. Conclusions: These studies demonstrate that naltrexone increases the subjective effects of oral THC. Thus, oral THC's effects are enhanced rather than antagonized by opioid receptor blockade in heavy marijuana smokers.

Revue / Journal Title

Psychopharmacologia   ISSN 0033-3158   CODEN PSYPAG 

Source / Source

2003, vol. 166, n^o1, pp. 77-85 [9 page(s) (article)] (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Springer, Berlin, ALLEMAGNE  (1959) (Revue)

Mots-clés anglais / English Keywords

Spermatophyta ; Angiospermae ; Dicotyledones ; Cannabidaceae ; Morphinan derivatives ; Opiates ; Heart rate ; Blood pressure ; Performance ; Oral administration ; Narcotic analgesic ; Cigarette ; Drug poison interaction ; Narcotic antagonist ; Naltrexone ; Biological activity ; Human ; Methadone ; Cannabis sativa ; Drug addiction ;

Mots-clés français / French Keywords

Spermatophyta ; Angiospermae ; Dicotyledones ; Cannabidaceae ; Morphinane dérivé ; Opiacés ; Rythme cardiaque ; Pression sanguine ; Performance ; Voie orale ; Analgésique narcotique ; Cigarette ; Interaction toxique médicament ; Antagoniste analgésique narcotique ; Naltrexone ; Activité biologique ; Homme ; Cannabinol(6a,7,8,10a-tétrahydro) ; Méthadone ; Cannabis sativa ; Toxicomanie ;

Mots-clés espagnols / Spanish Keywords

Spermatophyta ; Angiospermae ; Dicotyledones ; Cannabidaceae ; Morphinano derivado ; Opiados ; Ritmo cardíaco ; Presión sanguínea ; Rendimiento ; Vía oral ; Analgésico narcotico ; Cigarrillo ; Interacción sustancia tóxica medicamento ; Antagonista narcótico ; Naltrexona ; Actividad biológica ; Hombre ; Metadona ; Cannabis sativa ; Toxicomanía ;

Mots-clés d'auteur / Author Keywords

Opioid ; Cannabinoid ; Marijuana ; Choice ; Methadone ;

Localisation / Location

INIST-CNRS, Cote INIST : 1761, 35400011072205.0090