Titre du document / Document title

Effect of supplementing a high-fat, low-carbohydrate enteral formula in COPD patients

Auteur(s) / Author(s)

BAIQIANG CAI ; YUANJUE ZHU ; YI MA ; ZUOJUN XU ; YI ZAO ; JINELAN WANG ; YAOGUANG LIN ; COMER Gail M. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Chinese Academy of Medical Science, Beijing, CHINE
Abbott Laboratories, Abbott Park, Illinois, ETATS-UNIS

Résumé / Abstract

OBJECTIVE: One of the goals in treating patients with chronic obstructive pulmonary disease (COPD) who suffer from hypoxemia, hypercapnia, and malnutrition is to correct the malnutrition without increasing the respiratory quotient and minimize the production of carbon dioxide. This 3-wk study evaluated the efficacy of feeding a high-fat, low-carbohydrate (CHO) nutritional supplement as opposed to a high-carbohydrate diet in COPD patients on parameters of pulmonary function. METHODS: Sixty COPD patients with low body weight (<90% ideal body weight) were randomized to the control group, which received dietary counseling for a high-CHO diet (15% protein, 20% to 30% fat, and 60% to 70% CHO), or the experimental group, which received two to three cans (237 mL/can) of a high-fat, low-CHO oral supplement (16.7% protein, 55.1% fat, and 28.2% CHO) in the evening as part of the diet. Measurements of lung function (forced expiratory volume in I s or volume of air exhaled in I s of maximal expiration, minute ventilation, oxygen consumption per unit time, carbon dioxide production in unit time, and respiratory quotient) and blood gases (pH, arterial carbon dioxide tension, and arterial oxygen tension) were taken at baseline and after 3 wk. RESULTS: Lung function measurements decreased significantly and forced expiratory volume increased significantly in the experimental group. CONCLUSION: This study demonstrates that pulmonary function in COPD patients can be significantly improved with a high-fat, low-CHO oral supplement as compared with the traditional high-CHO diet.

Revue / Journal Title

Nutrition   ISSN 0899-9007   CODEN NUTRER 

Source / Source

2003, vol. 19, n^o3, pp. 229-232 [4 page(s) (article)] (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1987) (Revue)

Mots-clés anglais / English Keywords

Bronchus disease ; Lung disease ; Respiratory disease ; Respiratory system ; Respiration ; Nutrition ; Resuscitation ; Macronutrient ; Human ; Pulmonary ventilation ; Respiratory quotient ; Chronic ; Obstructive pulmonary disease ; Blood gas ; Supplementation ; Nutritional status ; Feeding ; Enteral administration ; Carbohydrate ; Lipids ;

Mots-clés français / French Keywords

Bronche pathologie ; Poumon pathologie ; Appareil respiratoire pathologie ; Appareil respiratoire ; Respiration ; Nutrition ; Réanimation ; Macronutriment ; Homme ; Ventilation pulmonaire ; Quotient respiratoire ; Chronique ; Bronchopneumopathie obstructive ; Gaz sanguin ; Supplémentation ; Etat nutritionnel ; Alimentation ; Voie entérale ; Glucide ; Lipide ;

Mots-clés espagnols / Spanish Keywords

Bronquio patología ; Pulmón patología ; Aparato respiratorio patología ; Aparato respiratorio ; Respiración ; Nutrición ; Reanimación ; Macronutriente ; Hombre ; Ventilación pulmonar ; Cociente respiratorio ; Crónico ; Broncopneumopatía obstructiva ; Gas sanguíneo ; Suplementación ; Estado nutricional ; Alimentación ; Vía enteral ; Glúcido ; Lípido ;

Mots-clés d'auteur / Author Keywords

chronic obstructive pulmonary disease ; blood gases ; hypercapnia ; respiratory quotient ; respiratory function ;

Localisation / Location

INIST-CNRS, Cote INIST : 22165, 35400010395573.0020