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Titre du document / Document title

The effects of acute cigarette smoking on cognitive functioning in chronic schizophrenia

Auteur(s) / Author(s)

TRACY J. I. (1) ; MONACO C. (2) ; GIOVANNETTI T. (2) ; ABRAHAM G. (1) ; JOSIASSEN R. C. (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) MCP Hahnemann University, Philadelphia, ETATS-UNIS
(2) Drexel University, Philadelphia, ETATS-UNIS
(3) Norristown State Hospital Clinical Research Center, ETATS-UNIS

Résumé / Abstract

Introduction. The prevalence of cigarette smoking among patients with schizophrenia is high. Nicotine stimulates acetylcholine (ACh) transmission, and patients with schizophrenia may suffer from reduced ACh activity due to the combined effects of antipsychotic and antiparkinsonian drug treatment. The present study was designed to test whether cigarette smoking is, in part, an adaptive response among patients with schizophrenia to temporarily enhance cognitive functioning through an increase in ACh tone. Methods. Thirty-three inpatients with chronic schizophrenia treated with either clozapine (high in anticholinergicity) or risperidone (low anticholinergicity) were administrated a cognitive test battery under two experimental conditions : Acute Smocking and Abstinence. Results. Results showed a modest and fairly specific enhancement effect for smoking. During Acute Smoking a subset of patients on clopazine required less time to complete a test of attentional vigilance. Also, a significant interaction appeared such that subjects treated with clopazine demonstrated better discriminability under the Acute Smoking condition. Conclusions. The data are consistent with other findings suggesting a specific link between attentional functioning and nicotinic acetylcholine activity, and lend support to the cognitive enhancement hypothesis for cigarette smoking in terms of producing subtle benefits for selected functions in cognitively impaired schizophrenia patients who are experiencing mediction-related anticholinergic burden.

Revue / Journal Title

Cognitive neuropsychiatry    ISSN  1354-6805 

Source / Source

2000, vol. 5, no3, pp. 193-217 (2 p.3/4)

Langue / Language

Anglais

Editeur / Publisher

Psychology Press, Hove, ROYAUME-UNI  (1996) (Revue)

Mots-clés anglais / English Keywords

Schizophrenia

;

Tobacco smoking

;

Cognition

;

Cholinergic transmission

;

Acetylcholine

;

Vigilance

;

Attention

;

Chemotherapy

;

Treatment

;

Clozapine

;

Risperidone

;

Human

;

Psychosis

;

Antagonist

;

Dopamine receptor

;

Dopamine antagonist

;

Serotonine receptor

;

Serotonin antagonist

;

Mots-clés français / French Keywords

Schizophrénie

;

Tabagisme

;

Cognition

;

Transmission cholinergique

;

Acétylcholine

;

Vigilance

;

Attention

;

Chimiothérapie

;

Traitement

;

Clozapine

;

Rispéridone

;

Homme

;

Dibenzodiazépine

;

Psychose

;

Antagoniste

;

Récepteur dopaminergique

;

Antagoniste dopamine

;

Récepteur sérotoninergique

;

Antagoniste sérotonine

;

Mots-clés espagnols / Spanish Keywords

Esquizofrenia

;

Tabaquismo

;

Cognición

;

Transmisión colinérgica

;

Acetilcolina

;

Vigilancia

;

Atención

;

Quimioterapia

;

Tratamiento

;

Clozapina

;

Risperidona

;

Hombre

;

Psicosis

;

Antagonista

;

Receptor dopaminérgico

;

Antagonista dopamina

;

Receptor serotoninérgico

;

Antagonista serotonina

;

Localisation / Location

INIST-CNRS, Cote INIST : 26594, 35400009148769.0030

Nº notice refdoc (ud4) : 1455992



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