Titre du document / Document title

Relaxation of arterial smooth muscle by water-soluble derivatives of coenzyme Q (ubiquinone)

Auteur(s) / Author(s)

BINDU R. ; VENKATARAMAN B. V. ; RAO Aparna V. S. ; RAMASARMA T. ;

Résumé / Abstract

Treatment of coenzyme Q with ozone, permanganate, and ferrous sulfate in presence of ascorbate or hydrogen peroxide yielded water-soluble degradation products, possibly having truncated side-chain and modified ring.These derivatives, but not the intact lipid-quinone, showed relaxation of phenylephrine-contracted rat arterial rings. Representative samples of these also decreased blood pressure when injected into the femoral vein in the rat.These effects offer an explanation for the hypotensive action of exogenous coenzyme Q regardless of its side-chain length.

Revue / Journal Title

Indian journal of biochemistry & biophysics    ISSN  0301-1208   CODEN IJBBBQ 

Source / Source

2003, vol. 40, n^o1, pp. 5-13 [9 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Council of Scientific & Industrial Research, New Delhi, INDE  (1971) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 9312, 35400010409481.0010