Titre du document / Document title

Low-dose intraoperative mitomycin-C versus conjunctival autograft in primary pterygium surgery : Long term follow-up

Auteur(s) / Author(s)

SHARMA A. ⁽¹⁾ ; GUPTA Amit ⁽¹⁾ ; RAM J. ⁽¹⁾ ; GUPTA Amod ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, INDE

Résumé / Abstract

■ PURPOSE: To evaluate and compare the long term safety and efficacy of low-dose intraoperative application of mitomycin-C (0.02%) with conjunctival autograft in primary pterygium surgery. ■ PATIENTS AND METHODS: Of 37 consecutive patients 41 eyes with primary pterygium underwent pterygium excision with either intraoperative mitomycin-C (0.02%) (Group I) or conjunctival autografts (Group II) at random. Mitomycin-C (0.2 mg/mL) was applied for 2.5 minutes on the scleral bed under the conjunctiva. Conjunctival autograft was obtained from upper temporal limbus and secured with 10-0 monofilament nylon. The follow-up period ranged from 14 to 54 months (mean 36 months) for mitomycin-C group and 13 to 58 months (mean 38 months) for conjunctival autograft group. ■ RESULTS: Twenty-one eyes underwent pterygium excision with intraoperative mitomycin-C (0.02%) application (Group I) and 20 eyes were treated using conjunctival autograft (Group II). The mean size of the pterygium was 3.80 mm (range 2.6 to 4.8 mm) in the mitomycin-C group and 3.60 mm (range 2.5 to 4.5 mm) in the conjunctival autograft group. Two (9.52%) eyes treated with intraoperative mitomycin-C had delayed epithelial healing of corneoscleral wound and one (4.76%) eye developed pyogenic granuloma. Three (14.3%) of the 21 eyes in Group I and one (5%) of 20 eyes in Group II had recurrence of pterygium (P = 0.3174). All recurrences occurred in patients below 40 years of age (P = 0.0384). ■ CONCLUSION: We conclude that conjunctival autograft and intraoperative mitomycin-C are both equally effective adjuncts to primary pterygium surgery on long term follow-up. However, future prospective studies with larger numbers of subjects may be carried out to find out the optimum concentration and duration of intraoperative mitomycin-C application.

Revue / Journal Title

Ophthalmic surgery and lasers   ISSN 1082-3069   CODEN OSLAF2 

Source / Source

2000, vol. 31, n^o4, pp. 301-307 (41 ref.)

Langue / Language

Anglais

Editeur / Publisher

Slack, Thorofare, NJ, ETATS-UNIS  (1995-2000) (Revue)

Mots-clés anglais / English Keywords

Pterygium ; Combined treatment ; Exeresis ; Mitomycin ; Antimitotic ; Antimetabolic ; Antibiotic ; Chemotherapy ; Intraoperative ; Low dose ; Autograft ; Conjunctiva ; Eye ; Follow up study ; Human ; Eye disease ; Conjunctiva disease ; Surgery ;

Mots-clés français / French Keywords

Ptérygion ; Traitement associé ; Exérèse ; Mitomycine ; Antimitotique ; Antimétabolite ; Antibiotique ; Chimiothérapie ; Peropératoire ; Dose faible ; Autogreffe ; Conjonctive ; Oeil ; Etude longitudinale ; Homme ; Oeil pathologie ; Conjonctive pathologie ; Chirurgie ;

Mots-clés espagnols / Spanish Keywords

Pterigión ; Tratamiento asociado ; Exéresis ; Mitomicina ; Antimitótico ; Antimetabólito ; Antibiótico ; Quimioterapia ; Peroperatorio ; Dosis débil ; Autoinjerto ; Conjuntiva ; Ojo ; Estudio longitudinal ; Hombre ; Ojo patología ; Conjuntiva patología ; Cirugía ;

Localisation / Location

INIST-CNRS, Cote INIST : 14946, 35400009031437.0060