Titre du document / Document title

The effects of cadmium on placental endocrine function

Auteur(s) / Author(s)

HENSON Michael C. ^{(1 2)} ; ANDERSON Mary B. ^{(2 3 4)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Obstetrics and Gynecology, Tulane University School of Medicine, New Orleans, Louisiana, ETATS-UNIS
⁽²⁾ The Interdisciplinary Program in Molecular and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana, ETATS-UNIS
⁽³⁾ Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana, ETATS-UNIS
⁽⁴⁾ The Center for Bioenvironmental Research of the Tulane University School of Medicine, New Orleans, Louisiana, ETATS-UNIS
Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, ETATS-UNIS

Résumé / Abstract

Cadmium is a ubiquitous trace metal in the environment and a constituent of tobacco smoke. It is sequestered in the placenta, where it accumulates with advancing gestation, potentially inhibiting the synthesis and/or release of hormones produced by the trophoblast. It is also possible that cadmium competes with essential metals for binding to metallothionein, thus interfering with the transport of these micronutrients to the developing fetus. Experiments in our laboratory indicate that the production of p r o g e s t e r o n e by syncytiotrophoblast cells in vitro is inhibited by cadmium and that this inhibition may be due to a decline in low density lipoprotein-receptor transcription. Although syncytiotrophoblastic maturation does not appear to be affected by cadmium exposure, further studies will be needed to determine the metal's potential effect on cytotrophoblastic invasion of the uterine endometrium in early gestation.

Revue / Journal Title

Recent research developments in endocrinology 

Source / Source

Recent research developments in endocrinology. Vol. 1 (2000) ; Part I
, pp. 37-47 [Document : 11 p.] (78 ref.) ISBN 81-86846-60-3 ;

Langue / Language

Anglais

Editeur / Publisher

INDE  (Revue)

Mots-clés anglais / English Keywords

Hormone ; Hormonal regulation ; Endocrinology ;

Mots-clés français / French Keywords

Hormone ; Régulation hormonale ; Endocrinologie ;

Mots-clés espagnols / Spanish Keywords

Hormona ; Regulación hormonal ; Endocrinología ;

Localisation / Location

INIST-CNRS, Cote INIST : L 28297, 35400010808682.0020