Titre du document / Document title

Serum levels of glucose-derived advanced glycation end products are associated with the severity of diabetic retinopathy in type 2 diabetic patients without renal dysfunction

Auteur(s) / Author(s)

KOGA K. ⁽¹⁾ ; YAMAGISHI S. ⁽¹⁾ ; OKAMOTO T. ⁽¹⁾ ; INAGAKI Y. ⁽¹⁾ ; AMANO S. ⁽¹⁾ ; TAKEUCHI M. ⁽²⁾ ; MAKITA Z. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, JAPON
⁽²⁾ Department of Biochemistry, Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, JAPON

Résumé / Abstract

Reducing sugars can react nonenzymatically with the amino groups of proteins to form Amadori products and subsequently cross-linked, heterogeneous fluorescent derivatives called advanced glycation end products (AGE). AGE can arise in vivo from various types of reducing sugars or dicarbonyl compounds and their formation and accumulation are known to progress during normal aging. In individuals with diabetes mellitus, this progression is greatly accelerated. The aim of the present study was to investigate which kinds of serum AGE components were associated with the severity of diabetic retinopathy in 72 type 2 diabetic patients without renal dysfunction. Serum levels of glucose-, glyceraldehyde- or methylglyoxal-derived AGE (methyl-AGE) were measured by an enzyme-linked immunosorbent assay No significant correlations were found between serum levels of various AGE and HbA_1c level, current age, systolic and diastolic pressure, diabetes duration, serum creatinine or blood urea nitrogen level in type 2 diabetic patients. A significant elevation of serum glucose-AGE was found to be associated with severity of diabetic retinopathy While no differences in serum methylAGE levels were found between patients with diabetic retinopathy and those without, serum levels of glyceraldehyde-AGE showed a tendency to increase as normal retinal status advanced to simple and proliferative retinopathy (p = 0.06). The present results suggest that among various types of AGE, glucose-AGE serum levels may be a useful marker of diabetic retinopathy in type 2 diabetic patients without renal dysfunction.

Revue / Journal Title

International journal of clinical pharmacology research   ISSN 0251-1649   CODEN CPHRDE 

Source / Source

2002, vol. 22, n^o1, pp. 13-17 [5 page(s) (article)] (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Bioscience Ediprint, Geneva, SUISSE  (1981) (Revue)

Mots-clés anglais / English Keywords

Endocrinopathy ; Eye disease ; Human ; Predictive factor ; Serum ; Biological fluid ; Non insulin dependent diabetes ; Biological marker ; Renal function ; Glycation ; Glycated protein ; Quantitative analysis ; Complication ; Diabetes mellitus ; Retinopathy ;

Mots-clés français / French Keywords

Endocrinopathie ; Oeil pathologie ; Homme ; Facteur prédictif ; Sérum ; Liquide biologique ; Diabète non insulinodépendant ; Marqueur biologique ; Fonction rénale ; Glycation ; Protéine glyquée ; Analyse quantitative ; Complication ; Diabète ; Rétinopathie ;

Mots-clés espagnols / Spanish Keywords

Endocrinopatía ; Ojo patología ; Hombre ; Factor predictivo ; Suero ; Líquido biológico ; Diabetes no insulinodependiente ; Marcador biológico ; Función renal ; Glicación ; Proteína glicada ; Análisis cuantitativo ; Complicación ; Diabetes ; Retinopatía ;

Localisation / Location

INIST-CNRS, Cote INIST : 20233, 35400010535400.0030