Titre du document / Document title
Diacylglycerol kinases: Regulation and signaling roles
Auteur(s) / Author(s)
TOPHAM Matthew K.
(1) ;
PRESCOTT Stephen M.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, ETATS-UNIS
Résumé / Abstract
Diacylglycerol kinases (DGKs) are thought to attenuate diacylglycerol signals by converting diacylglycerol to phosphatidic acid. The nine mammalian diacylglycerol kinases that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution. The activity of DGKs is regulated by mechanisms that can modify their access to diacylglycerol, affect their activity, or alter their ability to bind to other proteins. Although little is known of the specific function of DGKs in platelets, they likely influence actin reorganization and other signaling events requiring diacylglycerol.
Revue / Journal Title
Thrombosis and haemostasis
ISSN 0340-6245
CODEN THHADQ
Source / Source
2002, vol. 88, n
o6, pp. 912-918 [7 page(s) (article)] (70 ref.)
Langue / Language
Anglais
Editeur / Publisher
Schattauer, Stuttgart, ALLEMAGNE
(1976)
(Revue)
Mots-clés anglais / English Keywords
Enzyme ;
Transferases ;
Review ;
Animal ;
Human ;
Phosphatidic acid ;
Diacylglycerol ;
Diacylglycerol kinase ;
Regulation(control) ;
Signal transduction ;
Cell biology ;
Platelet function ;
Platelet ;
Mots-clés français / French Keywords
Enzyme ;
Transferases ;
Article synthèse ;
Animal ;
Homme ;
Acide phosphatidique ;
Diacylglycérol ;
Diacylglycerol kinase ;
Régulation ;
Transduction signal ;
Biologie cellulaire ;
Fonction thrombocytaire ;
Thrombocyte ;
Mots-clés espagnols / Spanish Keywords
Enzima ;
Transferases ;
Artículo síntesis ;
Animal ;
Hombre ;
Acido fosfatídico ;
Diacilglicerol ;
Diacylglycerol kinase ;
Regulación ;
Transducción señal ;
Biología celular ;
Función trombocitaria ;
Trombocito ;
Mots-clés d'auteur / Author Keywords
Diacylglycerol kinases ;
diacylglycerol ;
phosphatidic acid ;
Localisation / Location
INIST-CNRS, Cote INIST : 10255, 35400010753243.0060
Nº notice refdoc (ud4) : 14501164
