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Titre du document / Document title

Correlation between some discrimination functions and hemoglobin E

Auteur(s) / Author(s)

ITTARAT Wanida (1) ; RAYATONG Ornjira (1) ; ONGCHAROENJAI Sunaree (1) ; PIRAT Nontawit (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok 10700, THAILANDE

Résumé / Abstract

The most widely used discriminant functions and red cell indicies for differential diagnosis of thalassemia traits from iron deficiency anemia were evaluated for their abilities to identify HbE-containing blood samples. The functions were as follows : Fl= 0.01 x MCH x (MCV)2 ; F2 = RDW x MCH x (MCV)2 / Hb x 100; F3 = MCV/RBC; and F4 = MCH/RBC. Other red cell parameters including RDW, hemoglobin content, mean cell volume, mean cell hemoglobin as well as red cell counts, were also evaluated to distinguish HbE from the normal population. Hemoglobin electrophoresis was used as a comfirmatory test. The results showed that Fl, F2 and F3 as well as other red cell parameters of HbE-containing samples were different from those of HbA2A-containing red cells although there was no statistical significance. However, F4 and MCHC showed no difference between the two groups. It can be concluded from the present study that identification of hemoglobin E especially the heterozygous form by using parameters from an electronic cell counter is not easy. Discriminant functions and red cell indicies might be used as an initial diagnosis. But comfirmation is needed in all cases. Applying the MCV of 80 fl will miss 5 per cent of hemoglobin E carrier but will not miss the homozygous form.

Revue / Journal Title

Chot Mai Het Thang Phaet    ISSN  0125-2208   CODEN JMTHBU 

Source / Source

2000, vol. 83, no3, pp. 259-265 [7 page(s) (article)] (36 ref.)

Langue / Language

Anglais

Editeur / Publisher

Medical Association of Thailand, Bangkok, THAILANDE  (1919) (Revue)

Mots-clés anglais / English Keywords

Sideropenia

;

Genetic disease

;

Hemoglobinopathy

;

Hemolytic anemia

;

Hemopathy

;

Human

;

Heterogeneity

;

Hemoglobin E

;

Electrophoresis

;

Discriminant function

;

Iron deficiency anemia

;

Differential diagnostic

;

Clinical biology

;

Thalassemia

;

Mots-clés français / French Keywords

Sidéropénie

;

Maladie héréditaire

;

Hémoglobinopathie

;

Anémie hémolytique

;

Hémopathie

;

Homme

;

Hétérogénéité

;

Hémoglobine E

;

Electrophorèse

;

Fonction discriminante

;

Anémie ferriprive

;

Diagnostic différentiel

;

Biologie clinique

;

Thalassémie

;

Mots-clés espagnols / Spanish Keywords

Sideropenia

;

Enfermedad hereditaria

;

Hemoglobinopatía

;

Anemia hemolítica

;

Hemopatía

;

Hombre

;

Heterogeneidad

;

Hemoglobina E

;

Electroforesis

;

Función discriminante

;

Anemia ferropénica

;

Diagnóstico diferencial

;

Biología clínica

;

Talasemia

;

Localisation / Location

INIST-CNRS, Cote INIST : 17480, 35400010366541.0070

Nº notice refdoc (ud4) : 14453504



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