Titre du document / Document title

The role of insulin in human brain glucose metabolism: An ¹⁸fluoro-deoxyglucose positron emission tomography study

Auteur(s) / Author(s)

BINGHAM Emma M. ⁽¹⁾ ; HOPKINS David ⁽²⁾ ; SMITH Diarmuid ⁽¹⁾ ; PERNET Andrew ⁽¹⁾ ; HALLETT William ⁽³⁾ ; REED Laurence ⁽⁴⁾ ; MARSDEN Paul K. ⁽³⁾ ; AMIEL Stephanie A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ GKT School of Medicine, King's College Hospital, London, ROYAUME-UNI
⁽²⁾ Department Diabetes, Central Middlesex Hospital, London, ROYAUME-UNI
⁽³⁾ PET Centre, St Thomas' Hospital, London, ROYAUME-UNI
⁽⁴⁾ Institute of Psychiatry, Maudsley Hospital, London, ROYAUME-UNI

Résumé / Abstract

The effect of basal insulin on global and regional brain glucose uptake and metabolism in humans was studied using 18-fluorodeoxyglucose and positron emission tomography (FDG-PET). Eight healthy male volunteers aged 49.3 ± 5.1 years were studied twice in random order. On each occasion, they received an infusion of 0.1 mg . kg^-1 . min^-1 somatostatin to suppress endogenous insulin production. In one study 0.3 mU . kg^-1 . min^-1 insulin was infused to replace basal circulating insulin levels, and in the other study a saline infusion was used as control. We sought stimulatory effects of basal insulin on brain glucose metabolism particularly in regions with deficiencies in the blood-brain barrier and high density of insulin receptors. Insulin levels were 27.07 ± 1.3 mU/l with insulin replacement and 3.51 ± 0.4 mU/l without (P = 0.001). Mean global rate of brain glucose utilization was 0.215 ± 0.030 mmol . kg^-1 . min^-1 without insulin and 0.245 ± 0.021 mmol . kg^-1 . min^-1 with insulin (P = 0.008, an average difference of 15.3 ± 12.5%). Regional analysis using statistical parametric mapping showed that the effect of basal insulin was significantly less in the cerebellum (Z = 5.53, corrected P = 0.031). We conclude that basal insulin has a role in regulating global brain glucose uptake in humans, mostly marked in cortical areas.

Revue / Journal Title

Diabetes   ISSN 0012-1797   CODEN DIAEAZ 

Source / Source

2002, vol. 51, n^o12, pp. 3384-3390 [7 page(s) (article)] (48 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Diabetes Association, Alexandria, VA, ETATS-UNIS  (1952) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 8261, 35400010550961.0050