Titre du document / Document title

Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity

Auteur(s) / Author(s)

RENN C. N. ⁽¹⁾ ; STRAFF W. ⁽¹⁾ ; DORFMÜLLER A. ⁽¹⁾ ; AL-MASAOUDI T. ⁽¹⁾ ; MERK H. F. ⁽¹⁾ ; SACHS B. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Dermatology and Allergology, University Hospitals, Rheinisch-Westfãlische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, ALLEMAGNE

Résumé / Abstract

Background Teenagers and young adults frequently develop maculopapular exanthema following amoxicillin intake within infectious mononucleosis. The underlying pathomechanisms are still largely unknown. Objectives To investigate whether amoxicillin-induced exanthema in florid infectious mononucleosis is a disease-associated phenomenon or results from specific sensitization to the drug. Methods Four patients with amoxicillin-induced exanthema within infectious mononucleosis were analysed in vivo by prick, intradermal and patch tests and in vitro by means of the lymphocyte transformation test (LTT) employing amoxicillin, ampicillin, benzylpenicillin and phenoxymethylpenicillin. Results Drug-specific sensitization to amoxicillin in the LTT was observed in three patients, two of whom showed a side-chain-specific sensitization to amoxicillin and ampicillin. The in vitro results were confirmed in vivo by skin tests. Conclusions These data suggest that real sensitization to amoxicillin and ampicillin may occur within infectious mononucleosis and may be detected in vivo and in vitro by means of skin tests and the LTT.

Revue / Journal Title

British journal of dermatology   ISSN 0007-0963   CODEN BJDEAZ 

Source / Source

2002, vol. 147, n^o6, pp. 1166-1170 [5 page(s) (article)] (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1951) (Revue)

Mots-clés anglais / English Keywords

Skin disease ; Immunopathology ; Human ; Infection ; Viral disease ; β-Lactams ; Penicillin derivatives ; Young adult ; Pathogenesis ; Reactivity ; Lymphocyte transformation test ; Skin test ; Antibacterial agent ; Antibiotic ; Amoxicillin ; Skin ; Toxicity ; Exanthema ; Allergy ; Infectious mononucleosis ;

Mots-clés français / French Keywords

Peau pathologie ; Immunopathologie ; Homme ; Infection ; Virose ; β-Lactamines ; Pénicilline dérivé ; Adulte jeune ; Pathogénie ; Réactivité ; Test transformation lymphoblastique ; Test cutané ; Antibactérien ; Antibiotique ; Amoxicilline ; Peau ; Toxicité ; Exanthème ; Allergie ; Mononucléose infectieuse ;

Mots-clés espagnols / Spanish Keywords

Piel patología ; Inmunopatología ; Hombre ; Infección ; Virosis ; β-Lactams ; Penicilinas ; Adulto joven ; Patogenia ; Reactividad ; Prueba transformación linfoblástica ; Prueba cutáneo ; Antibacteriano ; Antibiótico ; Amoxicilina ; Piel ; Toxicidad ; Exantema ; Alergia ; Mononucleosis infecciosa ;

Mots-clés d'auteur / Author Keywords

amoxicillin ; drug allergy ; infectious mononucleosis ; lymphocyte transformation test ; patch test ;

Localisation / Location

INIST-CNRS, Cote INIST : 1043, 35400010695147.0090