Titre du document / Document title

A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes

Auteur(s) / Author(s)

CASTANEDA Carmen ⁽¹⁾ ; LAYNE Jennifer E. ⁽¹⁾ ; MUNOZ-ORIANS Leda ⁽¹⁾ ; GORDON Patricia L. ⁽¹⁾ ; WALSMITH Joseph ⁽¹⁾ ; FOLDVARI Mona ⁽¹⁾ ; ROUBENOFF Ronenn ⁽¹⁾ ; TUCKER Katherine L. ⁽¹⁾ ; NELSON Miriam E. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, ETATS-UNIS

Résumé / Abstract

OBJECTIVE-To determine the efficacy of high-intensity progressive resistance training (PRT) on glycemic control in older adults with type 2 diabetes. RESEARCH DESIGN AND METHODS-We performed a 16-week randomized controlled trial in 62 Latino older adults (40 women and 22 men; mean ± SE age 66 ± 8 years) with type 2 diabetes randomly assigned to supervised PRT or a control group. Glycemic control, metabolic syndrome abnormalities, body composition, and muscle glycogen stores were determined before and after the intervention. RESULTS-Sixteen weeks of PRT (three times per week) resulted in reduced plasma glycosylated hemoglobin levels (from 8.7 ± 0.3 to 7.6 ± 0.2%), increased muscle glycogen stores (from 60.3 ± 3.9 to 79.1 ± 5.0 mmol glucose/kg muscle), and reduced the dose of prescribed diabetes medication in 72% of exercisers compared with the control group, P = 0.004-0.05. Control subjects showed no change in glycosylated hemoglobin, a reduction in muscle glycogen (from 61.4 ± 7.7 to 47.2 ± 6.7 mmol glucose/kg muscle), and a 42% increase in diabetes medications. PRT subjects versus control subjects also increased lean mass (+1.2 ± 0.2 vs. -0.1 ± 0.1 kg), reduced systolic blood pressure (-9.7 ± 1.6 vs. +7.7 ± 1.9 mmHg), and decreased trunk fat mass (-0.7 ± 0.1 vs. +0.8 ± 0.1 kg; P = 0.01-0.05). CONCLUSIONS - PRT as an adjunct to standard of care is feasible and effective in improving glycemic control and some of the abnormalities associated with the metabolic syndrome among high-risk older adults with type 2 diabetes.

Revue / Journal Title

Diabetes care   ISSN 0149-5992   CODEN DICAD2 

Source / Source

2002, vol. 25, n^o12, pp. 2335-2341 [7 page(s) (article)] (38 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Diabetes Association, Alexandria, VA, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Endocrinopathy ; Experimental study ; Statistical analysis ; Chemotherapy ; Treatment ; Glycogen ; Metabolic storage ; Hemoglobin A1c ; Body mass index ; Glycemia ; Endurance ; Physical exercise ; Randomization ; Elderly ; Human ; Non insulin dependent diabetes ;

Mots-clés français / French Keywords

Endocrinopathie ; Etude expérimentale ; Analyse statistique ; Chimiothérapie ; Traitement ; Glycogène ; Réserve métabolique ; Hémoglobine A1c ; Indice masse corporelle ; Glycémie ; Endurance ; Exercice physique ; Randomisation ; Personne âgée ; Homme ; Diabète non insulinodépendant ;

Mots-clés espagnols / Spanish Keywords

Endocrinopatía ; Estudio experimental ; Análisis estadístico ; Quimioterapia ; Tratamiento ; Glicógeno ; Reserva metabólica ; Hemoglobina A1c ; Indice masa corporal ; Glucemia ; Aguante ; Ejercicio físico ; Aleatorización ; Anciano ; Hombre ; Diabetes no insulinodependiente ;

Localisation / Location

INIST-CNRS, Cote INIST : 18054, 35400010549872.0350