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Titre du document / Document title

Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines

Auteur(s) / Author(s)

HO Chi-Kuan (1) ; HUANG Yu-Ling (2) ; CHEN Chieh-Chih (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Medical Research & Education, Veterans General Hospital, Taipei, TAIWAN, PROVINCE DE CHINE
(2) National Research Institute of Chinese Medicine, TAIWAN, PROVINCE DE CHINE

Résumé / Abstract

Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs. We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs. Our results have shown that one of the xanthone derivatives which could be identified as garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that garcinone E may be potentially useful for the treatment of certain types of cancer.

Revue / Journal Title

Planta medica    ISSN  0032-0943   CODEN PLMEAA 

Source / Source

2002, vol. 68, no11, pp. 975-979 [5 page(s) (article)] (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1953) (Revue)

Mots-clés anglais / English Keywords

Asia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Guttiferae

;

Cell culture

;

Korea

;

Folk medicine

;

Xanthone

;

Extract

;

Fruit

;

Hepatoprotector

;

Digestive system

;

Liver

;

Hepatocyte

;

Malignant tumor

;

Tumor cell

;

In vitro

;

Biological activity

;

Antineoplastic agent

;

Pharmacognosy

;

Medicinal plant

;

Plant origin

;

Mots-clés français / French Keywords

Asie

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Guttiferae

;

Garcinia mangostana

;

Culture cellulaire

;

Corée

;

Médecine traditionnelle

;

Xanthone

;

Extrait

;

Fruit

;

Hépatoprotecteur

;

Appareil digestif

;

Foie

;

Hépatocyte

;

Tumeur maligne

;

Cellule tumorale

;

In vitro

;

Activité biologique

;

Anticancéreux

;

Pharmacognosie

;

Plante médicinale

;

Origine végétale

;

Mots-clés espagnols / Spanish Keywords

Asia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Guttiferae

;

Cultivo celular

;

Corea

;

Medicina tradicional

;

Xantona

;

Extracto

;

Fruto

;

Hepatoprotector

;

Aparato digestivo

;

Hígado

;

Hepatocito

;

Tumor maligno

;

Célula tumoral

;

In vitro

;

Actividad biológica

;

Anticanceroso

;

Farmacognosia

;

Planta medicinal

;

Origen vegetal

;

Mots-clés d'auteur / Author Keywords

Garcinone E

;

xanthones

;

hepatocellular carcinoma

;

chemotherapy

;

Garcinia mangostana

;

Guttiferae

;

Localisation / Location

INIST-CNRS, Cote INIST : 9624, 35400010691096.0060

Nº notice refdoc (ud4) : 14372891



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